The diagnosis of multiple sclerosis is based on neurological symptoms and signs, alongside
evidence of dissemination of CNS lesions in space and time. MRI is often sufficient to …

Neuronal injury is a universal event that occurs in disease processes that affect both the
central and peripheral nervous systems. A blood biomarker linked to neuronal injury would …

The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in
research and clinical practice. Scientific advances in the past 7 years suggest that they might …

Importance Progression independent of relapse activity (PIRA) is the main event responsible
for irreversible disability accumulation in relapsing multiple sclerosis (MS). Objective To …

New evidence and consensus has led to further revision of the McDonald Criteria for
diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of …

Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple
sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria …

Survival of plasma cells is regulated by B-cell maturation antigen (BCMA), a membrane-
bound receptor activated by its agonist ligands BAFF and APRIL. Here we report that γ …

Background and objective: We explored which clinical and biochemical variables predict
conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis …

Multiple sclerosis (MS), is a chronic disease of the central nervous system (CNS)
characterized by loss of motor and sensory function, that results from immune-mediated …

New diagnostic criteria for multiple sclerosis integrating magnetic resonance image
assessment with clinical and other paraclinical methods were introduced in 2001. The …