Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …

Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …

Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-
extracellular matrix interactions. For instance, normal epithelial cells maintain tissue …

Circulating tumor cells (CTCs) are vital components of liquid biopsies for diagnosis of
residual cancer, monitoring of therapy response, and prognosis of recurrence. Scientific …

The analysis of circulating tumor cells (CTCs) is an outstanding tool to provide insights into
the biology of metastatic cancers, to monitor disease progression and with potential for use …

The mutational and phenotypic landscape of tumors is dynamic, requiring constant
monitoring of cancer patients to provide the most up-to-date and effective care. Circulating …

Decades of efforts in engineering in vitro cancer models have advanced drug discovery and
the insight into cancer biology. However, the establishment of preclinical models that enable …

Traditionally, the metastasis has been detected in the late stage of the cancer, which mostly
leads to death. The classical opinion about tumor metastasis is that tumor cell migration …

The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor
microemboli, in biological fluids has long been described. Intensive research on single …

Circulating tumour cell (CTC) clusters have been proposed to be major players in the
metastatic spread of breast cancer, particularly during advanced disease stages. Yet, it is …