Platinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of
human neoplasms. Their clinical success is, however, limited due to severe side effects and …

Much success has been achieved with platinum-based chemotherapeutic agents, ie through
interactions with DNA. The long-term application of Pt complexes is thwarted by issues …

Since its approval in 1979 cisplatin has become an important component in chemotherapy
regimes for the treatment of ovarian, testicular, lung and bladder cancers, as well as …

Increasing numbers of DNA structures are being revealed using biophysical, spectroscopic
and genomic methods. The diversity of transition metal complexes is also growing, as the …

Over twenty years of intensive work toward improvement of cisplatin, and with hundreds of
platinum drugs tested, has resulted in the introduction of the widely used carboplatin and of …

Many international researchers have strived to understand the mechanism of action or
improve the efficacy of inorganic coordination compounds that have been identified to …

The application of inorganic chemistry to medicine is a rapidly developing field, and novel
therapeutic and diagnostic metal complexes are now having an impact on medical practice …

In the next two decades, the world is expected to see around 20 million cases of cancer.
Moreover, the types of cancer will vary considerably from country to other. Therefore, all …

Cellular DNA is susceptible to chemical modifications when exposed to various
environmental agents, chemotherapeutic agents, or endogenous agents produced by …

The importance of platinum drugs in cancer chemotherapy is underscored by the clinical
success of cisplatin [cis-diamminedichloroplatinum (II)] and its analogues and by clinical …