Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

[HTML][HTML] Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

KL Wyres, KE Holt - Current opinion in microbiology, 2018 - Elsevier
Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency
and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant …

[HTML][HTML] Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae

KL Wyres, RR Wick, LM Judd, R Froumine… - PLoS …, 2019 - journals.plos.org
Klebsiella pneumoniae has emerged as an important cause of two distinct public health
threats: multi-drug resistant (MDR) healthcare-associated infections and drug susceptible …

Next generation sequencing approaches to evaluate water and wastewater quality

E Garner, BC Davis, E Milligan, MF Blair, I Keenum… - Water Research, 2021 - Elsevier
The emergence of next generation sequencing (NGS) is revolutionizing the potential to
address complex microbiological challenges in the water industry. NGS technologies can …

[HTML][HTML] Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low-and middle-income countries

MJ Carvalho, K Sands, K Thomson, E Portal… - Nature …, 2022 - nature.com
Early development of the microbiome has been shown to affect general health and physical
development of the infant and, although some studies have been undertaken in high-income …

The threat of carbapenem-resistant bacteria in the environment: Evidence of widespread contamination of reservoirs at a global scale

MC Mills, J Lee - Environmental Pollution, 2019 - Elsevier
Environmental reservoirs of antibiotic resistance (AR) are a growing concern that are
gathering more attention as potential sources for human infection. Carbapenem-resistant …

[HTML][HTML] Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia

KL Wyres, TNT Nguyen, MMC Lam, LM Judd… - Genome medicine, 2020 - Springer
Background Klebsiella pneumoniae is a leading cause of bloodstream infection (BSI).
Strains producing extended-spectrum beta-lactamases (ESBLs) or carbapenemases are …

Genomic analysis of hospital plumbing reveals diverse reservoir of bacterial plasmids conferring carbapenem resistance

RA Weingarten, RC Johnson, S Conlan, AM Ramsburg… - MBio, 2018 - Am Soc Microbiol
The hospital environment is a potential reservoir of bacteria with plasmids conferring
carbapenem resistance. Our Hospital Epidemiology Service routinely performs extensive …

[HTML][HTML] Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumoniae

M Nguyen, T Brettin, SW Long, JM Musser, RJ Olsen… - Scientific reports, 2018 - nature.com
Antimicrobial resistant infections are a serious public health threat worldwide. Whole
genome sequencing approaches to rapidly identify pathogens and predict antibiotic …

[HTML][HTML] Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in Klebsiella pneumoniae

MMC Lam, KL Wyres, LM Judd, RR Wick, A Jenney… - Genome medicine, 2018 - Springer
Background Klebsiella pneumoniae is a recognised agent of multidrug-resistant (MDR)
healthcare-associated infections; however, individual strains vary in their virulence potential …