Abstract The updated International Consensus Classification (ICC) of B-acute lymphoblastic
leukemia (B-ALL) and T-acute lymphoblastic leukemia (T-ALL) includes both revisions to …

Acute lymphoblastic leukemia (ALL) is a heterogeneous group of hematologic malignancies
characterized by abnormal proliferation of immature lymphoid cells. It is the most commonly …

The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …

Acute lymphoblastic leukemia (ALL) is the most successful paradigm of how risk-adapted
therapy and detailed understanding of the genetic alterations driving leukemogenesis and …

Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether
acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger …

Recently, we described B-cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype
with an early switch to the monocytic lineage and the loss of the B-cell immunophenotype …

PURPOSE Although cure rates for childhood acute lymphoblastic leukemia (ALL) exceed
90%, ALL remains a leading cause of cancer death in children. Half of relapses arise in …

Genomic analyses have revolutionized our understanding of the biology of B-progenitor
acute lymphoblastic leukemia (ALL). Studies of thousands of cases across the age spectrum …

Genomic aberrations—gene fusions in the majority of cases—and corresponding
transcriptional regulations define an increasingly complex landscape of molecular subtypes …