Gap junctions consist of arrays of intercellular channels that enable adjacent cells to
communicate both electrically and metabolically. Gap junctions have a wide diversity of …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Communication is important to ensure the correct and efficient flow of information, which is
required to sustain active social networks. A fine-tuned communication between cells is vital …

Connexins are widely distributed proteins in the body that are crucially important for heart
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …

Gap Junction (GJ) channels, including the most common Connexin 43 (Cx43), have
fundamental roles in excitable tissues by facilitating rapid transmission of action potentials …

The maintenance of tissue, organ, and organism homeostasis relies on an intricate network
of players and mechanisms that assist in the different forms of cell–cell communication …

Rationale: Delivery of Cx43 (connexin 43) to the intercalated disc is a continuous and rapid
process critical for intercellular coupling. By a pathway of targeted delivery involving …

Abstract Connexin 43 (Cx43) is the major connexin protein in ventricular cardiomyocytes.
Six Cx43 proteins assemble into so-called hemichannels at the sarcolemma and opposing …

Connexin-43 (Cx43) gap junctions provide intercellular coupling, which ensures rapid action
potential propagation and synchronized heart contraction. Alterations in Cx43 localization …