Studying human respiratory disease in animals–role of induced and naturally occurring models

K Williams, J Roman - The Journal of pathology, 2016 - Wiley Online Library
Respiratory disorders like asthma, emphysema, and pulmonary fibrosis affect millions of
Americans and many more worldwide. Despite advancements in medical research that have …

The potential role of IL-33/ST2 signaling in fibrotic diseases

Q Gao, Y Li, M Li - Journal of Leucocyte Biology, 2015 - academic.oup.com
IL-33, a new member of the IL-1F, is widely expressed throughout the body and can be up-
regulated by stimulation with proinflammatory factors. It has been identified as a functional …

Bryodulcosigenin attenuates bleomycin‐induced pulmonary fibrosis via inhibiting AMPK‐mediated mesenchymal epithelial transition and oxidative stress

Y Ding, L Wang, B Liu, G Ren, R Okubo… - Phytotherapy …, 2022 - Wiley Online Library
Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs
in several organs, including the lungs. Bryodulcosigenin (BDG) is a cucurbitane‐type …

LncRNA CTD-2528L19. 6 prevents the progression of IPF by alleviating fibroblast activation

T Chen, Y Guo, J Wang, L Ai, L Ma, W He, Z Li… - Cell Death & …, 2021 - nature.com
Long non-coding RNAs (lncRNAs) have emerged as critical factors for regulating multiple
biological processes during organ fibrosis. However, the mechanism of lncRNAs in …

Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers

Y Wang, J Yella, J Chen, FX McCormack… - BMC pulmonary …, 2017 - Springer
Abstract Background Idiopathic Pulmonary Fibrosis (IPF) is a fatal fibrotic lung disease
occurring predominantly in middle-aged and older adults. The traditional diagnostic …

Idiopathic pulmonary fibrosis in West Highland white terriers: An update

C Clercx, A Fastrès, E Roels - The Veterinary Journal, 2018 - Elsevier
Canine idiopathic pulmonary fibrosis (CIPF) affects middle-aged to older dogs of a single
breed, mainly the West Highland white terrier (WHWT), which is suggestive of a genetic …

Further characterization of computed tomographic and clinical features for staging and prognosis of idiopathic pulmonary fibrosis in West Highland white terriers

F Thierry, I Handel, G Hammond… - Veterinary radiology …, 2017 - Wiley Online Library
Idiopathic pulmonary fibrosis is an interstitial lung disease of unknown etiology resulting in
progressive interstitial fibrosis, with a known predilection in West Highland white terriers. In …

Protective effect of ginsenoside Rg1 on bleomycin-induced pulmonary fibrosis in rats: involvement of caveolin-1 and TGF-β1 signal pathway

H Zhan, F Huang, W Ma, Z Zhao, H Zhang… - Biological and …, 2016 - jstage.jst.go.jp
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis and high
mortality rate. Panax Notoginseng Saponins (PNS), extracted from Panax Notoginseng as a …

Yangyin Yiqi Mixture Ameliorates Bleomycin‐Induced Pulmonary Fibrosis in Rats through Inhibiting TGF‐β1/Smad Pathway and Epithelial to Mesenchymal Transition

L Meng, X Zhang, H Wang, H Dong… - Evidence‐Based …, 2019 - Wiley Online Library
Objective. The aim of the current study was to investigate the protective effect of Yangyin Yiqi
Mixture (YYYQ) on Bleomycin‐induced pulmonary fibrosis in rats based on TGF‐β1/Smad …

Matrix metalloproteinase‐2,‐7, and‐9 activities in dogs with idiopathic pulmonary fibrosis compared to healthy dogs and dogs with other respiratory diseases

M Määttä, HP Laurila, S Holopainen… - Journal of Veterinary …, 2021 - Wiley Online Library
Background Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, interstitial lung
disease that mainly affects West Highland white terriers (WHWTs) and is characterized by …