▪ Abstract Completion of the cell cycle requires the temporal and spatial coordination of
chromosome segregation with mitotic spindle disassembly and cytokinesis. In budding …

A conserved signalling cascade—termed the mitotic-exit network in budding yeast and the
septation-initiation network in fission yeast—controls key events during exit from mitosis and …

Cytokinesis is the final event of the cell division cycle, and its completion results in
irreversible partition of a mother cell into two daughter cells. Cytokinesis was one of the first …

Centrosomes, spindle pole bodies, and related structures in other organisms are a
morphologically diverse group of organelles that share a common ability to nucleate and …

Septins perform diverse functions through the formation of filaments and higher-order
structures. However, the exact architecture of septin structures remains unclear. In the …

The ubiquitin system drives the cell division cycle by the timely destruction of numerous
regulatory proteins. Remarkably, the two main activities that catalyze substrate ubiquitination …

Cell growth is an essential requirement for cell cycle progression. While it is often held that
growth is independent of cell cycle position, this relationship has not been closely …

Proper completion of mitosis requires careful coordination of numerous cellular events. It is
crucial, for example, that cells do not initiate spindle disassembly and cytokinesis until …

Inactivation of mitotic cyclin-dependent kinases (Cdks) is required for cells to exit mitosis [1,
2]. In the budding yeast Saccharomyces cerevisiae, Cdk inactivation is triggered by the …

The fission yeast Schizosaccharomyces pombe divides by medial fission through the use of
an actomyosin contractile ring. Precisely at the end of anaphase, the ring begins to constrict …