The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic has posed a
huge threat to global health because of its rapid spread and various mutant variants. Critical …

Our understanding of the involvement of the gut microbiota (GM) in human health has
expanded exponentially over the last few decades, particularly in the fields of metabolism …

Schizophrenia and bipolar disorder share a number of common features, both
symptomatically and biologically. Abnormalities in the neuroimmune and the stress …

Over the last decades, our understanding of adaptive immune responses to solid organ
transplantation increased considerably and allowed development of immunosuppressive …

Currently, kidney transplantation is the best treatment option for kidney failure for a majority
of eligible patients. It is associated with a better quality of life and reduced mortality as …

Introduction: Despite major advances in kidney transplant, glucocorticoids (GCs) or steroids
remain one of the mainstay treatments. They possess adverse events (AEs) that are related …

The number of elderly people has increased considerably over the last decades, due to a
rising life expectancy and ageing populations. As a result, an increased number of elderly …

Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the
covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these …

Importance The complications of corticosteroids make the inclusion of these drugs in
immunosuppressive protocols for kidney transplant patients undesirable. However …

Liposomes can be seen as ideal carriers for anti-inflammatory drugs as their ability to
(passively) target sites of inflammation and release their content to inflammatory target cells …