Studying and modelling dynamic biological processes using time-series gene expression data
Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …
multiple time points. The most abundant source of information regarding such dynamic …
[HTML][HTML] Impulse control: temporal dynamics in gene transcription
N Yosef, A Regev - Cell, 2011 - cell.com
Regulatory circuits controlling gene expression constantly rewire to adapt to environmental
stimuli, differentiation cues, and disease. We review our current understanding of the …
stimuli, differentiation cues, and disease. We review our current understanding of the …
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
We demonstrate an integrated approach to build, test, and refine a model of a cellular
pathway, in which perturbations to critical pathway components are analyzed using DNA …
pathway, in which perturbations to critical pathway components are analyzed using DNA …
Adaptive prediction of environmental changes by microorganisms
Natural habitats of some microorganisms may fluctuate erratically, whereas others, which
are more predictable, offer the opportunity to prepare in advance for the next environmental …
are more predictable, offer the opportunity to prepare in advance for the next environmental …
Regulatory on/off minimization of metabolic flux changes after genetic perturbations
Predicting the metabolic state of an organism after a gene knockout is a challenging task,
because the regulatory system governs a series of transient metabolic changes that …
because the regulatory system governs a series of transient metabolic changes that …
Classes of fast and specific search mechanisms for proteins on DNA
Problems of search and recognition appear over different scales in biological systems. In
this review we focus on the challenges posed by interactions between proteins, in particular …
this review we focus on the challenges posed by interactions between proteins, in particular …
Genome‐wide transcriptional plasticity underlies cellular adaptation to novel challenge
Cells adjust their transcriptional state to accommodate environmental and genetic
perturbations. An open question is to what extent transcriptional response to perturbations …
perturbations. An open question is to what extent transcriptional response to perturbations …
The unforeseen challenge: from genotype-to-phenotype in cell populations
E Braun - Reports on Progress in Physics, 2015 - iopscience.iop.org
Biological cells present a paradox, in that they show simultaneous stability and flexibility,
allowing them to adapt to new environments and to evolve over time. The emergence of …
allowing them to adapt to new environments and to evolve over time. The emergence of …
Central carbon metabolism of Saccharomyces cerevisiae in anaerobic, oxygen-limited and fully aerobic steady-state conditions and following a shift to anaerobic …
MG Wiebe, E Rintala, A Tamminen… - FEMS Yeast …, 2008 - academic.oup.com
Abstract Saccharomyces cerevisiae CEN. PK113-1A was grown in glucose-limited
chemostat culture with 0%, 0.5%, 1.0%, 2.8% or 20.9% O2 in the inlet gas (D= 0.10 h− 1, pH …
chemostat culture with 0%, 0.5%, 1.0%, 2.8% or 20.9% O2 in the inlet gas (D= 0.10 h− 1, pH …
Metabolic cost of rapid adaptation of single yeast cells
G Woronoff, P Nghe, J Baudry… - Proceedings of the …, 2020 - National Acad Sciences
Cells can rapidly adapt to changing environments through nongenetic processes; however,
the metabolic cost of such adaptation has never been considered. Here we demonstrate …
the metabolic cost of such adaptation has never been considered. Here we demonstrate …