Phosphate as a signaling molecule and its sensing mechanism

T Michigami, M Kawai, M Yamazaki… - Physiological …, 2018 - journals.physiology.org
In mammals, phosphate balance is maintained by influx and efflux via the intestines,
kidneys, bone, and soft tissue, which involves multiple sodium/phosphate (Na+/Pi) …

Mechanisms of phosphate transport

M Levi, E Gratton, IC Forster, N Hernando… - Nature Reviews …, 2019 - nature.com
Over the past 25 years, successive cloning of SLC34A1, SLC34A2 and SLC34A3, which
encode the sodium-dependent inorganic phosphate (Pi) cotransport proteins 2a–2c, has …

Phosphate transport in epithelial and nonepithelial tissue

N Hernando, K Gagnon, E Lederer - Physiological reviews, 2021 - journals.physiology.org
Phosphate is an essential nutrient for life and is a critical component of bone formation, a
major signaling molecule, and structural component of cell walls. Phosphate is also a …

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability

AJ King, M Siegel, Y He, B Nie, J Wang… - Science translational …, 2018 - science.org
Hyperphosphatemia is common in patients with chronic kidney disease and is increasingly
associated with poor clinical outcomes. Current management of hyperphosphatemia with …

Inflammation: a putative link between phosphate metabolism and cardiovascular disease

J Voelkl, D Egli-Spichtig, I Alesutan… - Clinical Science, 2021 - portlandpress.com
Dietary habits in the western world lead to increasing phosphate intake. Under physiological
conditions, extraosseous precipitation of phosphate with calcium is prevented by a mineral …

1,25(OH)2 vitamin D3 stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine

N Hernando, EM Pastor‐Arroyo, J Marks… - The Journal of …, 2021 - Wiley Online Library
Key points Intestinal absorption of phosphate proceeds via an active/transcellular route
mostly mediated by NaPi‐IIb/Slc34a2 and a poorly characterized passive/paracellular …

Paracellular transport of phosphate along the intestine

T Knöpfel, N Himmerkus, D Günzel… - American Journal …, 2019 - journals.physiology.org
Inorganic phosphate (Pi) is crucial for many biological functions, such as energy
metabolism, signal transduction, and pH buffering. Efficient systems must exist to ensure …

Renal phosphate handling and inherited disorders of phosphate reabsorption: an update

CA Wagner, I Rubio-Aliaga, N Hernando - Pediatric Nephrology, 2019 - Springer
Renal phosphate handling critically determines plasma phosphate and whole body
phosphate levels. Filtered phosphate is mostly reabsorbed by Na+-dependent phosphate …

The emerging role of phosphorus in human health

RP Bird, NAM Eskin - Advances in food and Nutrition Research, 2021 - Elsevier
Phosphorus, an essential nutrient, performs vital functions in skeletal and non-skeletal
tissues and is pivotal for energy production. The last two decades of research on the …

The role of SLC34A2 in intestinal phosphate absorption and phosphate homeostasis

J Marks - Pflügers Archiv-European Journal of Physiology, 2019 - Springer
There has recently been significant interest in the concept of directly targeting intestinal
phosphate transport to control hyperphosphatemia in patients with chronic kidney disease …