Mercury (Hg) toxicity continues to represent a global health concern. Given that human
populations are mostly exposed to low chronic levels of mercurial compounds …

Homocysteine, an amino acid containing a sulfhydryl group, is an intermediate product
during metabolism of the amino acids methionine and cysteine. Hyperhomocysteinemia is …

Background Depression is highly prevalent in patients with diabetes mellitus (DM). Diabetic
depression has been shown to be associated with low-grade systemic inflammation. In …

Glutamate serves as the dominant central nervous system (CNS) excitatory neurotransmitter,
in part by activating N-methyl-D-aspartate receptors (NMDARs). While the structure, function …

Background: Excessive proliferation and apoptosis resistance in pulmonary vascular cells
underlie vascular remodeling in pulmonary arterial hypertension (PAH). Specific treatments …

Platelets are anucleate cells that circulate in blood and are essential components of the
hemostatic system. During aging, platelet numbers decrease and their aggregation capacity …

The process of proplatelet formation (PPF) requires coordinated interaction between
megakaryocytes (MKs) and the extracellular matrix (ECM), followed by a dynamic …

Cardiovascular diseases (CVDs) are the leading cause of death globally—partly a
consequence of increased population size and ageing—and are major contributors to …

Dantrolene (DTN) is a ryanodine receptor (RyR) antagonist that inhibits Ca2+ release from
stores in the sarcoplasmic reticulum. DTN is mainly used in the management of malignant …

We developed and validated gas chromatography–mass spectrometry (GC–MS) methods
for the simultaneous measurement of amino acids and their metabolites in 10-µL aliquots of …