The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …

Glucose-6-phosphatase catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose
and inorganic phosphate. It is a multicomponent system located in the endoplasmic …

Several studies have shown that healthy individuals with fasting plasma glucose (FPG)
levels at the high end of the normal range have an increased risk of mortality. To identify …

Glucose is a basic nutrient in most of the creatures; its transport through biological
membranes is an absolute requirement of life. This role is fulfilled by glucose transporters …

Identifying the genetic variants that regulate fasting glucose concentrations may further our
understanding of the pathogenesis of diabetes. We therefore investigated the association of …

Key transcription factors control the gene expression program in mature pancreatic β‐cells,
but their integration into regulatory networks is little understood. Here, we show that Insm1 …

Elevated fasting blood glucose (FBG) is associated with increased risk for the development
of type 2 diabetes and cardiovascular-associated mortality. Genome-wide association …

Background Single nucleotide polymorphisms (SNPs) from GCK, GCKR, G6PC2 and
MTNR1B were found to modulate the fasting glucose levels. The current study aimed to …

G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit, primarily expressed
in pancreatic islet β cells, which modulates the sensitivity of insulin secretion to glucose and …

CD8+ T cells play an important role in the development of type 1 diabetes (T1D) in NOD
mice and humans. IGRP (islet-specific glucose-6-phosphatase catalytic subunit-related …