Vitamin D shows a variety of pleiotropic activities which cannot be fully explained by the
stimulation of classic pathway-and vitamin D receptor (VDR)-dependent transcriptional …

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

The immune system has evolved to protect the host from a universe of pathogenic microbes
that are themselves constantly evolving. The immune system also helps the host eliminate …

The genomic actions of the vitamin D are mediated via its biologically most potent metabolite
1α, 25‐dihydroxyvitamin D3 (1, 25 (OH) 2D3) and the transcription factor vitamin D receptor …

Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …

The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the
endoplasmic reticulum that is essential for establishing a hierarchical immune response …

Vitamin D is a major steroid hormone that is gaining attention as a therapeutic molecule.
Due to the general awareness of its importance for the overall well-being, vitamin D …

Disulfide bond formation is probably involved in the biogenesis of approximately one third of
human proteins. A central player in this essential process is protein disulfide isomerase or …

The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER
quality control (ERQC) system. The ERQC facilitates folding and modification of secretory …

A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at
the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter …