Tau-targeting therapies for Alzheimer disease: current status and future directions

EE Congdon, C Ji, AM Tetlow, Y Jiang… - Nature Reviews …, 2023 - nature.com
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

Tau-targeting therapies for Alzheimer disease

EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

C Xie, XX Zhuang, Z Niu, R Ai, S Lautrup… - Nature Biomedical …, 2022 - nature.com
A reduced removal of dysfunctional mitochondria is common to aging and age-related
neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating …

Cryo-EM structures of tau filaments from Alzheimer's disease

AWP Fitzpatrick, B Falcon, S He, AG Murzin… - Nature, 2017 - nature.com
Alzheimer's disease is the most common neurodegenerative disease, and there are no
mechanism-based therapies. The disease is defined by the presence of abundant …

Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

L Jiang, W Lin, C Zhang, PEA Ash, M Verma, J Kwan… - Molecular cell, 2021 - cell.com
The microtubule-associated protein tau oligomerizes, but the actions of oligomeric tau
(oTau) are unknown. We have used Cry2-based optogenetics to induce tau oligomers (oTau …

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease

G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos… - Science …, 2021 - science.org
Both the replication of protein aggregates and their spreading throughout the brain are
implicated in the progression of Alzheimer's disease (AD). However, the rates of these …

[HTML][HTML] A method for the acute and rapid degradation of endogenous proteins

D Clift, WA McEwan, LI Labzin, V Konieczny… - Cell, 2017 - cell.com
Methods for the targeted disruption of protein function have revolutionized science and
greatly expedited the systematic characterization of genes. Two main approaches are …

Propagation of tau aggregates and neurodegeneration

M Goedert, DS Eisenberg… - Annual review of …, 2017 - annualreviews.org
A pathway from the natively unfolded microtubule-associated protein Tau to a highly
structured amyloid fibril underlies human Tauopathies. This ordered assembly causes …

[HTML][HTML] Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

C Laurent, L Buée, D Blum - Biomedical journal, 2018 - Elsevier
Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common
type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD …

A walk through tau therapeutic strategies

S Jadhav, J Avila, M Schöll, GG Kovacs… - Acta neuropathologica …, 2019 - Springer
Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …