Detrusor underactivity, or underactive bladder (UAB), is defined as a contraction of reduced
strength and/or duration resulting in prolonged bladder emptying and/or a failure to achieve …

The case is compelling for the involvement of nerve growth factor (NGF) in the pathogenesis
of lower urinary tract disease, especially in conditions with altered neural function …

Purpose: Urinary incontinence and overactive bladder are important and common
conditions that have received little general medical attention. We reviewed the magnitude …

Diabetes mellitus (DM) is at epidemic proportions and becoming a major problem in the
USA. According to the Centers for Disease Control and Prevention, 18 million people in the …

In the last two decades, nerve growth factor (NGF), initially described as a prototypical
trophic factor in the development of sensory and sympathetic innervation, has emerged as a …

Diabetes mellitus is a chronic metabolic disease, posing a considerable threat to global
public health. Treating systemic comorbidities has been one of the greatest clinical …

Prior studies have demonstrated an association between visceral inflammation, an increase
in nerve growth factor (NGF) expression, and development of hyperalgesia. Because …

Dysfunction of the lower urinary tract (LUT) including urinary bladder and urethra (and
prostate in men) is one of the most frequent complications of diabetes and can manifest as …

• Introduction• Methods of gene delivery‐Non‐viral techniques‐Naked DNA‐Cationic
liposomes‐Viral techniques‐Retrovirus‐Adenovirus‐Adeno‐associated virus‐Herpes …

Peripheral neuropathy is a common and debilitating complication of diabetes. In animal
models, neurotrophic factors can prevent progression of the neuropathy, but adverse effects …