Next-generation sequencing technology has rapidly accelerated the discovery of genetic
variants of interest in individuals with rare diseases. However, showing that these variants …

Zebrafish have been widely used as a model system for studying developmental processes,
but in the last decade, they have also emerged as a valuable system for modeling human …

The zebrafish has become a widely used model organism because of its fecundity, its
morphological and physiological similarity to mammals, the existence of many genomic tools …

A great challenge in neuroscience is understanding how activity in the brain gives rise to
behavior. The zebrafish is an ideal vertebrate model to address this challenge, thanks to the …

Zebra fish may be an ideal vertebrate model system for numerous human diseases with
which the genetics and biological mechanisms of the disease may be studied. Zebra fish …

Most behaviors, even simple innate reflexes, are mediated by circuits of neurons spanning
areas throughout the brain. However, in most cases, the distribution and dynamics of firing …

In vivo studies represent an essential step in drug development and currently rely largely on
mice, yet limitations of mammalian models motivated the search for complementary …

To track and control self-location, animals integrate their movements through space.
Representations of self-location are observed in the mammalian hippocampal formation, but …

The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification
of the roles of specific genes and signaling pathways in development. The zebrafish …

Inventive genetic screens in zebrafish are revealing new genetic pathways that control
vertebrate development, disease and behaviour. By exploiting the versatility of zebrafish …