A central role for thiols in plant tolerance to abiotic stress
Abiotic stress poses major problems to agriculture and increasing efforts are being made to
understand plant stress response and tolerance mechanisms and to develop new tools that …
understand plant stress response and tolerance mechanisms and to develop new tools that …
A review on metronidazole: an old warhorse in antimicrobial chemotherapy
D Leitsch - Parasitology, 2019 - cambridge.org
The 5-nitroimidazole drug metronidazole has remained the drug of choice in the treatment of
anaerobic infections, parasitic as well as bacterial, ever since its development in 1959. In …
anaerobic infections, parasitic as well as bacterial, ever since its development in 1959. In …
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target
A Debnath, D Parsonage, RM Andrade, C He… - Nature medicine, 2012 - nature.com
Entamoeba histolytica, a protozoan intestinal parasite, is the causative agent of human
amebiasis. Amebiasis is the fourth leading cause of death and the third leading cause of …
amebiasis. Amebiasis is the fourth leading cause of death and the third leading cause of …
Drug resistance in Giardia duodenalis
BRE Ansell, MJ McConville, SY Ma'ayeh… - Biotechnology …, 2015 - Elsevier
Giardia duodenalis is a microaerophilic parasite of the human gastrointestinal tract and a
major contributor to diarrheal and post-infectious chronic gastrointestinal disease world …
major contributor to diarrheal and post-infectious chronic gastrointestinal disease world …
Low-molecular-mass antioxidants in parasites
RL Krauth-Siegel, AE Leroux - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: Parasitic infections continue to be a major problem for global human health.
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …
[HTML][HTML] Entamoeba thiol-based redox metabolism: A potential target for drug development
Amebiasis is an intestinal infection widespread throughout the world caused by the human
pathogen Entamoeba histolytica. Metronidazole has been a drug of choice against …
pathogen Entamoeba histolytica. Metronidazole has been a drug of choice against …
Efflux pumps and antimicrobial resistance: Paradoxical components in systems genomics
Efflux pumps play a major role in the increasing antimicrobial resistance rendering a large
number of drugs of no use. Large numbers of pathogens are becoming multidrug resistant …
number of drugs of no use. Large numbers of pathogens are becoming multidrug resistant …
Sulfate Activation in Mitosomes Plays an Important Role in the Proliferation of Entamoeba histolytica
Mitochondrion-related organelles, mitosomes and hydrogenosomes, are found in a
phylogenetically broad range of organisms. Their components and functions are highly …
phylogenetically broad range of organisms. Their components and functions are highly …
Redox pathways as drug targets in microaerophilic parasites
D Leitsch, CF Williams, I Hrdý - Trends in parasitology, 2018 - cell.com
The microaerophilic parasites Entamoeba histolytica, Trichomonas vaginalis, and Giardia
lamblia jointly cause hundreds of millions of infections in humans every year. Other …
lamblia jointly cause hundreds of millions of infections in humans every year. Other …
Digestive exophagy of biofilms by intestinal amoeba and its impact on stress tolerance and cytotoxicity
E Zanditenas, M Trebicz-Geffen, D Kolli… - npj Biofilms and …, 2023 - nature.com
The human protozoan parasite Entamoeba histolytica is responsible for amebiasis, a
disease endemic to developing countries. E. histolytica trophozoites colonize the large …
disease endemic to developing countries. E. histolytica trophozoites colonize the large …