Defining trained immunity and its role in health and disease

MG Netea, J Domínguez-Andrés, LB Barreiro… - Nature Reviews …, 2020 - nature.com
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …

[HTML][HTML] Metazoan micrornas

DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

MicroRNAs as regulatory elements in immune system logic

A Mehta, D Baltimore - Nature Reviews Immunology, 2016 - nature.com
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

MiR-155: an important regulator of neuroinflammation

VD Zingale, A Gugliandolo, E Mazzon - International Journal of Molecular …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
at the post-transcriptional level and that play an important role in many cellular processes …

miR-146 and miR-155: two key modulators of immune response and tumor development

U Testa, E Pelosi, G Castelli, C Labbaye - Non-coding RNA, 2017 - mdpi.com
MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-
coding RNAs, 19–3 nucleotides in length, that negatively regulate protein coding gene …

Exosomal miR‐24‐3p impedes T‐cell function by targeting FGF11 and serves as a potential prognostic biomarker for nasopharyngeal carcinoma

SB Ye, H Zhang, TT Cai, YN Liu, JJ Ni… - The Journal of …, 2016 - Wiley Online Library
Recent studies have shown that extracellular microRNAs are not only potential biomarkers
but are also involved in cell interactions to regulate the intercommunication between cancer …

Negative regulation of cytokine signaling in immunity

A Yoshimura, M Ito, S Chikuma… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal
transducers and activators of transcription (JAK-STAT) pathway to promote gene …

The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types

JP Hsin, Y Lu, GB Loeb, CS Leslie, AY Rudensky - Nature immunology, 2018 - nature.com
Numerous microRNAs and their target mRNAs are coexpressed across diverse cell types.
However, it is unknown whether they are regulated in a manner independent of or …

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

A Dhawan, JG Scott, AL Harris, FM Buffa - Nature communications, 2018 - nature.com
Abstract microRNAs are key regulators of the human transcriptome across a number of
diverse biological processes, such as development, aging and cancer, where particular …

New insights into the epigenetic regulation of inflammatory bowel disease

J Xu, H Xu, M Yang, Y Liang, Q Peng… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa.
Environmental factors, genetics, intestinal microbiota, and the immune system are all …