Calcium phosphate nanoparticles-based systems for siRNA delivery

X Xu, Z Li, X Zhao, L Keen, X Kong - Regenerative Biomaterials, 2016 - academic.oup.com
Despite the enormous therapeutic potential of siRNA as a treatment strategy, the delivery is
still a problem due to unfavorable biodistribution profiles and poor intracellular …

Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy

J Li, S Wang, X Shi, M Shen - Advances in colloid and interface science, 2017 - Elsevier
The design and development of multifunctional nanoplatforms for biomedical applications
still remains to be challenging. This review reports the recent advances in aqueous-phase …

Efficient Delivery of Therapeutic siRNA by Fe3O4 Magnetic Nanoparticles into Oral Cancer Cells

L Jin, Q Wang, J Chen, Z Wang, H Xin, D Zhang - Pharmaceutics, 2019 - mdpi.com
The incidence of oral cancer is increasing due to smoking, drinking, and human
papillomavirus (HPV) infection, while the current treatments are not satisfactory. Small …

Cancer-targeted fucoidan‑iron oxide nanoparticles for synergistic chemotherapy/chemodynamic theranostics through amplification of P-selectin and oxidative stress

TL Ho, C Mutalik, L Rethi, HNT Nguyen… - International Journal of …, 2023 - Elsevier
A combination of chemotherapy and chemodynamic therapy (CDT) is being developed to
improve the theranostic efficacy and biological safety of current therapies. However, most …

[HTML][HTML] Anticancer polypyrrole-polyethylenimine drug-free nanozyme for precise B-cell lymphoma therapy

TT Nguyen, EY Chuang, YP Chen, PC Tseng… - Biomedicine & …, 2023 - Elsevier
As an alternative strategy for cancer treatment, the combination of cancer nanomedicine and
immunotherapy is promising with regard to efficacy and safety; however, precise modulation …

PEI-Coated Fe3O4 Nanoparticles Enable Efficient Delivery of Therapeutic siRNA Targeting REST into Glioblastoma Cells

R Wang, V Degirmenci, H Xin, Y Li, L Wang… - International journal of …, 2018 - mdpi.com
Glioblastomas (GBM) are the most frequent brain tumors lacking efficient treatment. The
increasingly elucidated gene targets make siRNA-based gene therapy a promising …

Human 3D cultures as models for evaluating magnetic nanoparticle CNS cytotoxicity after short-and repeated long-term exposure

U De Simone, M Roccio, L Gribaldo, A Spinillo… - International journal of …, 2018 - mdpi.com
Since nanoparticles (NPs) can translocate to the brain and impact the highly vulnerable
central nervous system (CNS), novel in vitro tools for the assessment of NP-induced …

Iron oxide nanoparticles with different polymer coatings for photothermal therapy

J Yang, L Fan, Y Xu, J Xia - Journal of Nanoparticle Research, 2017 - Springer
Iron oxide nanoparticles (Fe 3 O 4 NPs) have attracted significant attention in view of their
potential applications in biomedicine. Surface coatings or modifications are generally …

Multifunctional nanocarriers for delivering siRNA and miRNA in glioblastoma therapy: advances in nanobiotechnology-based cancer therapy

K Shetty, S Yasaswi, S Dutt, KS Yadav - 3 Biotech, 2022 - Springer
Glioblastoma multiforme (GBM) is one of the most lethal cancer due to poor diagnosis and
rapid resistance developed towards the drug. Genes associated to cancer-related …

Cysteamine functionalized gold nanoparticles exhibit high efficiency delivery of genetic materials in embryonic stem cells majorly via clathrin mediated endocytosis

F Fernandes, I Talukdar, M Kowshik - International Journal of …, 2024 - Elsevier
Efficient and safe gene delivery is vital for genetic manipulation of stem cells for regenerative
medicine. Gold nanoparticles have been used for various biomedical applications in the …