Interleukin‐23 pathway at the enthesis: The emerging story of enthesitis in spondyloarthropathy
C Bridgewood, K Sharif, J Sherlock… - Immunological …, 2020 - Wiley Online Library
The inflammatory disorders collectively termed the seronegative spondyloarthropathies
(SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the …
(SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the …
Bilobalide: A review of its pharmacology, pharmacokinetics, toxicity, and safety
J Lu, L Xie, K Liu, X Zhang, X Wang, X Dai… - Phytotherapy …, 2021 - Wiley Online Library
Bilobalide is a natural sesquiterpene trilactone from Ginkgo biloba leaves. It has good water
solubility and is widely used in food and pharmaceutical fields. In the last decade, a plethora …
solubility and is widely used in food and pharmaceutical fields. In the last decade, a plethora …
Evidence that tissue resident human enthesis γδT-cells can produce IL-17A independently of IL-23R transcript expression
RJ Cuthbert, A Watad, EM Fragkakis… - Annals of the …, 2019 - ard.bmj.com
Objectives Murine models of interleukin (IL)-23-driven spondyloarthritis (SpA) have
demonstrated entheseal accumulation of γδT-cells which were responsible for the majority …
demonstrated entheseal accumulation of γδT-cells which were responsible for the majority …
The Th17 pathway in vascular inflammation: culprit or consort?
M Robert, P Miossec, A Hot - Frontiers in Immunology, 2022 - frontiersin.org
The involvement of IL-17A in autoimmune and inflammatory diseases has prompted the
development of therapeutic strategies to block the Th17 pathway. Promising results came …
development of therapeutic strategies to block the Th17 pathway. Promising results came …
Why inhibition of IL-23 lacked efficacy in ankylosing spondylitis
The term spondyloarthritis pertains to both axial and peripheral arthritis including ankylosing
spondylitis (AS) and psoriatic arthritis (PsA), which is strongly linked to psoriasis and also …
spondylitis (AS) and psoriatic arthritis (PsA), which is strongly linked to psoriasis and also …
Successful use of secukinumab in two melanoma patients with immune checkpoint inhibitor-induced inflammatory arthropathy
VT Ma, CD Lao, LA Fecher, E Schiopu - Immunotherapy, 2022 - Taylor & Francis
Immune-related adverse events (irAEs) are a major concern when treating cancer patients
with immune checkpoint inhibitor (ICI) therapy. Selecting the most appropriate management …
with immune checkpoint inhibitor (ICI) therapy. Selecting the most appropriate management …
The novel cytokine Metrnl/IL-41 is elevated in psoriatic arthritis synovium and inducible from both entheseal and synovial fibroblasts
Abstract Meteorin-like (IL-41), is a novel cytokine that is thought to be immunoregulatory and
is highly expressed in psoriatic skin. We investigated IL-41 protein expression in synovial …
is highly expressed in psoriatic skin. We investigated IL-41 protein expression in synovial …
Loss and gain of bone in spondyloarthritis: what drives these opposing clinical features?
G Clunie, N Horwood - Therapeutic advances in …, 2020 - journals.sagepub.com
The breadth of bone lesion types seen in spondyloarthritis is unprecedented in medicine
and includes increased bone turnover, bone loss and fragility, osteitis, osteolysis and …
and includes increased bone turnover, bone loss and fragility, osteitis, osteolysis and …
Cytokines in the pathogenesis of large granular lymphocytic leukemia
C Isabelle, A Boles, N Chakravarti, P Porcu… - Frontiers in …, 2022 - frontiersin.org
Large granular lymphocytic leukemia (LGLL) is a lymphoproliferative disorder of older adults
characterized by the clonal expansion of cytotoxic T/natural killer cells due to constitutive pro …
characterized by the clonal expansion of cytotoxic T/natural killer cells due to constitutive pro …
Central sensitization, illness perception and obesity should be considered when interpreting disease activity in axial spondyloarthritis
SC Kieskamp, D Paap, MJG Carbo, F Wink… - …, 2021 - academic.oup.com
Objectives Many patients with axial spondyloarthritis (axSpA) report persistent pain even
when treated with anti-inflammatory agents. Our aim was to explore the presence of central …
when treated with anti-inflammatory agents. Our aim was to explore the presence of central …