Microglia are the tissue-resident macrophage population of the brain, specialized in
supporting the CNS environment and protecting it from endogenous and exogenous insults …

Cellular senescence is a state of terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells …

Alzheimer's disease (AD) and dementia in general are age-related diseases with multiple
contributing factors, including brain inflammation. Microglia, and specifically those …

Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …

Cellular senescence, a state of irreversible cell-cycle arrest caused by a variety of cellular
stresses, is critically involved in age-related tissue dysfunction in various organs. However …

Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's …

Gliomas are a diverse group of primary central nervous system neoplasms with no curative
therapies available. Brain macrophages comprise microglia in the brain parenchyma, border …

Cellular senescence is a process in which cells change their characteristic phenotype in
response to stress and enter a state of prolonged cell cycle arrest accompanied by a distinct …

Advancing age is a major risk factor of Alzheimer's disease (AD). The worldwide prevalence
of AD is approximately 50 million people, and this number is projected to increase …

Recent advances in genetic analysis and intensive research have revealed that microglial
cells respond to external stimuli in various ways and adopt diverse states. Herein, we …