In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …

Polyamines are polycationic organic amines that are required for all eukaryotic life,
exemplified by the polyamine spermidine, which plays an essential role in translation. They …

The T rypanosoma brucei procyclic form resides within the digestive tract of its insect vector,
where it exploits amino acids as carbon sources. Threonine is the amino acid most rapidly …

Prozymes are catalytically inactive enzyme paralogs that dramatically stimulate the function
of weakly active enzymes through complex formation. The two prozymes described to date …

Neglected tropical diseases transmitted by trypanosomatids include three major human
scourges that globally affect the world's poorest people: African trypanosomiasis or sleeping …

There is an urgent need for the identification and validation of new therapeutic targets in
protozoan parasites because currently available drugs are limited in number and …

Human African trypanosomiasis (HAT) is a fatal infectious disease caused by the eukaryotic
pathogen Trypanosoma brucei (Tb). Available treatments are difficult to administer and have …

Catalytically inactive enzyme paralogs occur in many genomes. Some regulate their active
counterparts but the structural principles of this regulation remain largely unknown. We …

Highlights•The African trypanosome is beginning to be understood as an integrated
system.•Genome, transcriptome, proteome and metabolome datasets are available and …