The ability of cancer cells to become cross-resistant to structurally and functionally unrelated
anti-cancer drugs is known as multidrug resistance. It has been recognized that multidrug …

A major side effect of cancer chemotherapy is myelosuppression. Expression of drug-
resistance genes in hematopoietic stem cells (HSC) using gene transfer methodologies …

MRP1 (multidrug resistance protein 1) co-exports glutathione (GSH) and drug (s) and
exports GSH, glucuronide, and sulphate-conjugated drugs. Human Fly-eco fibrosarcoma …

A major obstacle to hematopoietic gene therapy is the lack of appropriate in vivo selection
protocols that can raise the presently low numbers of gene-altered stem cells to …

Transfer of drug resistance genes into hematopoietic stem cells (HSCs) has promise for the
treatment of a variety of inherited, that is, X-linked severe combined immune deficiency …

Unstable expression of transferred genes is a major obstacle to successful gene therapy of
hematopoietic diseases. We have investigated in a canine large-animal model whether …

Hematopoietic stem cell gene therapy is potentially curative for a number of inherited and
acquired disorders. However, poor gene transfer and expression in repopulating …

Gene therapy promises intriguing new treatment options for a number of disabling and life-
threatening diseases. The treatment of cancer is one of the prime areas of application in …

Efficient selection of gene-modified cells is required for a number of potential gene therapy
applications, as well as molecular biology studies. Ideally, a clinical selection regimen would …

Myelosuppression represents a major side effect of cytotoxic anti-cancer agents. Infection
due to granulocytopenia and the risk of bleeding due to thrombocytopenia compromise the …