Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

Noncoding RNA s in disease

E Lekka, J Hall - FEBS letters, 2018 - Wiley Online Library
Noncoding RNA s are emerging as potent and multifunctional regulators in all biological
processes. In parallel, a rapidly growing number of studies has unravelled associations …

Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

YY Wu, HC Kuo - Journal of Biomedical Science, 2020 - Springer
Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly
expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific …

Mitochondrial dysfunction and neurological disorders: a narrative review and treatment overview

EE Alshial, MI Abdulghaney, AHS Wadan… - Life Sciences, 2023 - Elsevier
Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

The involvement of microRNAs in neurodegenerative diseases

S Maciotta, M Meregalli, Y Torrente - Frontiers in cellular …, 2013 - frontiersin.org
Neurodegenerative diseases (NDDs) originate from a loss of neurons in the central nervous
system and are severely debilitating. The incidence of NDDs increases with age, and they …

MicroRNAs dysregulation and mitochondrial dysfunction in neurodegenerative diseases

M Catanesi, M d'Angelo, MG Tupone… - International Journal of …, 2020 - mdpi.com
Neurodegenerative diseases are debilitating and currently incurable conditions causing
severe cognitive and motor impairments, defined by the progressive deterioration of …

Current status of microRNA-based therapeutic approaches in neurodegenerative disorders

S Paul, LA Bravo Vázquez, S Pérez Uribe… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) are a key gene regulator and play essential roles in several biological
and pathological mechanisms in the human system. In recent years, plenty of miRNAs have …

miRNAs: key players in neurodegenerative disorders and epilepsy

HK Karnati, MK Panigrahi, RK Gutti… - Journal of …, 2015 - content.iospress.com
MicroRNAs (miRNAs) are endogenous,∼ 22 nucleotide, non-coding RNA molecules that
function as post-transcriptional regulators of gene expression. miRNA dysregulation has …

miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement

AG Hoss, A Labadorf, JC Latourelle, VK Kartha… - BMC medical …, 2015 - Springer
Background MicroRNAs (miRNAs) are small non-coding RNAs that recognize sites of
complementarity of target messenger RNAs, resulting in transcriptional regulation and …

microRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases

I Basak, KS Patil, G Alves, JP Larsen… - Cellular and Molecular …, 2016 - Springer
The last decade has experienced the emergence of microRNAs as a key molecular tool for
the diagnosis and prognosis of human diseases. Although the focus has mostly been on …