Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets
T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …
the origin, course of action and treatment of any disease state is essential. A microscopic …
Noncoding RNA s in disease
E Lekka, J Hall - FEBS letters, 2018 - Wiley Online Library
Noncoding RNA s are emerging as potent and multifunctional regulators in all biological
processes. In parallel, a rapidly growing number of studies has unravelled associations …
processes. In parallel, a rapidly growing number of studies has unravelled associations …
Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases
YY Wu, HC Kuo - Journal of Biomedical Science, 2020 - Springer
Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly
expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific …
expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific …
Mitochondrial dysfunction and neurological disorders: a narrative review and treatment overview
Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …
The involvement of microRNAs in neurodegenerative diseases
S Maciotta, M Meregalli, Y Torrente - Frontiers in cellular …, 2013 - frontiersin.org
Neurodegenerative diseases (NDDs) originate from a loss of neurons in the central nervous
system and are severely debilitating. The incidence of NDDs increases with age, and they …
system and are severely debilitating. The incidence of NDDs increases with age, and they …
MicroRNAs dysregulation and mitochondrial dysfunction in neurodegenerative diseases
M Catanesi, M d'Angelo, MG Tupone… - International Journal of …, 2020 - mdpi.com
Neurodegenerative diseases are debilitating and currently incurable conditions causing
severe cognitive and motor impairments, defined by the progressive deterioration of …
severe cognitive and motor impairments, defined by the progressive deterioration of …
Current status of microRNA-based therapeutic approaches in neurodegenerative disorders
S Paul, LA Bravo Vázquez, S Pérez Uribe… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) are a key gene regulator and play essential roles in several biological
and pathological mechanisms in the human system. In recent years, plenty of miRNAs have …
and pathological mechanisms in the human system. In recent years, plenty of miRNAs have …
miRNAs: key players in neurodegenerative disorders and epilepsy
HK Karnati, MK Panigrahi, RK Gutti… - Journal of …, 2015 - content.iospress.com
MicroRNAs (miRNAs) are endogenous,∼ 22 nucleotide, non-coding RNA molecules that
function as post-transcriptional regulators of gene expression. miRNA dysregulation has …
function as post-transcriptional regulators of gene expression. miRNA dysregulation has …
miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement
Background MicroRNAs (miRNAs) are small non-coding RNAs that recognize sites of
complementarity of target messenger RNAs, resulting in transcriptional regulation and …
complementarity of target messenger RNAs, resulting in transcriptional regulation and …
microRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases
The last decade has experienced the emergence of microRNAs as a key molecular tool for
the diagnosis and prognosis of human diseases. Although the focus has mostly been on …
the diagnosis and prognosis of human diseases. Although the focus has mostly been on …