Epidemiology and risk-stratification of NAFLD-associated HCC

GN Ioannou - Journal of hepatology, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is projected to become the leading cause of
hepatocellular carcinoma (HCC) in many countries. Many risk factors for NAFLD are also …

Non-alcoholic fatty liver disease: metabolic, genetic, epigenetic and environmental risk factors

O Juanola, S Martínez-López, R Francés… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver
disease in the Western world, probably due to the growing prevalence of obesity, metabolic …

Update on NAFLD genetics: from new variants to the clinic

E Trépo, L Valenti - Journal of hepatology, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …

Immunological mechanisms and therapeutic targets of fatty liver diseases

H Wang, W Mehal, LE Nagy, Y Rotman - Cellular & Molecular …, 2021 - nature.com
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management

T Marjot, A Moolla, JF Cobbold, L Hodson… - Endocrine …, 2020 - academic.oup.com
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disease, extending from simple
steatosis to inflammation and fibrosis with a significant risk for the development of cirrhosis. It …

[PDF][PDF] Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population

H Gellert‐Kristensen, TG Richardson… - …, 2020 - Wiley Online Library
Background and Aims We hypothesized that a genetic risk score (GRS) for fatty liver disease
influences the risk of cirrhosis and hepatocellular carcinoma (HCC). Three genetic variants …

MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy

YX Xian, JP Weng, F Xu - Chinese medical journal, 2021 - mednexus.org
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, placing an increasing burden on human health. NAFLD is a complex …

the emerging role of genetics in precision medicine for patients with non‐alcoholic steatohepatitis

B Carlsson, D Lindén, G Brolén… - Alimentary …, 2020 - Wiley Online Library
Background Non‐alcoholic steatohepatitis (NASH) is a severe form of non‐alcoholic fatty
liver disease (NAFLD) characterised by liver fat accumulation, inflammation and progressive …

Biomarkers for hepatobiliary cancers

JC Nault, A Villanueva - Hepatology, 2021 - Wiley Online Library
The clinical management of primary liver cancers such as hepatocellular carcinoma (HCC)
and cholangiocarcinoma (CCA) has significantly changed in the last 3 years. The …

Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study

E Trépo, S Caruso, J Yang, S Imbeaud… - The Lancet …, 2022 - thelancet.com
Background Hepatocellular carcinoma is a frequent consequence of alcohol-related liver
disease, with variable incidence among heavy drinkers. We did a genome-wide association …