Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

SW Dickey, GYC Cheung, M Otto - Nature Reviews Drug Discovery, 2017 - nature.com
The rapid evolution and dissemination of antibiotic resistance among bacterial pathogens
are outpacing the development of new antibiotics, but antivirulence agents provide an …

Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives

SM Gygli, S Borrell, A Trauner… - FEMS microbiology …, 2017 - academic.oup.com
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques

K Dijkman, CC Sombroek, RAW Vervenne… - Nature medicine, 2019 - nature.com
Tuberculosis (TB) remains the deadliest infectious disease, and the widely used Bacillus
Calmette–Guérin (BCG) vaccine fails to curb the epidemic. An improved vaccination strategy …

The role of vaccines in preventing bacterial antimicrobial resistance

KU Jansen, C Knirsch, AS Anderson - Nature medicine, 2018 - nature.com
Antimicrobial resistance (AMR) and the associated morbidity and mortality due to bacterial
pathogens have been increasing globally to alarming levels. The World Health Organization …

[HTML][HTML] Tuberculosis 2015: burden, challenges and strategy for control and elimination

M Raviglione, G Sulis - Infectious disease reports, 2016 - pmc.ncbi.nlm.nih.gov
Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide, accounting for
about 9.6 million new cases and 1.5 million deaths annually. The poorest and socially …

Drug‐resistant tuberculosis: an update on disease burden, diagnosis and treatment

C Lange, D Chesov, J Heyckendorf, CC Leung… - …, 2018 - Wiley Online Library
The emergence of antimicrobial resistance against Mycobacterium tuberculosis, the leading
cause of mortality due to a single microbial pathogen worldwide, represents a growing threat …

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

A Zumla, M Rao, RS Wallis, SHE Kaufmann… - The Lancet Infectious …, 2016 - thelancet.com
Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …

The recombinant Bacille Calmette–Guérin vaccine VPM1002: ready for clinical efficacy testing

NE Nieuwenhuizen, PS Kulkarni, U Shaligram… - Frontiers in …, 2017 - frontiersin.org
The only licensed vaccine against tuberculosis (TB), bacille Calmette–Guérin (BCG),
protects against severe extrapulmonary forms of TB but is virtually ineffective against the …

Tuberculosis treatment and management—an update on treatment regimens, trials, new drugs, and adjunct therapies

A Zumla, J Chakaya, R Centis, L D'Ambrosio… - The Lancet …, 2015 - thelancet.com
WHO estimates that 9 million people developed active tuberculosis in 2013 and 1· 5 million
people died from it. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) …

[HTML][HTML] Host blood RNA signatures predict the outcome of tuberculosis treatment

EG Thompson, Y Du, ST Malherbe, S Shankar, J Braun… - Tuberculosis, 2017 - Elsevier
Biomarkers for tuberculosis treatment outcome will assist in guiding individualized treatment
and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of …