Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance
The rapid evolution and dissemination of antibiotic resistance among bacterial pathogens
are outpacing the development of new antibiotics, but antivirulence agents provide an …
are outpacing the development of new antibiotics, but antivirulence agents provide an …
Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …
Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques
K Dijkman, CC Sombroek, RAW Vervenne… - Nature medicine, 2019 - nature.com
Tuberculosis (TB) remains the deadliest infectious disease, and the widely used Bacillus
Calmette–Guérin (BCG) vaccine fails to curb the epidemic. An improved vaccination strategy …
Calmette–Guérin (BCG) vaccine fails to curb the epidemic. An improved vaccination strategy …
The role of vaccines in preventing bacterial antimicrobial resistance
KU Jansen, C Knirsch, AS Anderson - Nature medicine, 2018 - nature.com
Antimicrobial resistance (AMR) and the associated morbidity and mortality due to bacterial
pathogens have been increasing globally to alarming levels. The World Health Organization …
pathogens have been increasing globally to alarming levels. The World Health Organization …
[HTML][HTML] Tuberculosis 2015: burden, challenges and strategy for control and elimination
M Raviglione, G Sulis - Infectious disease reports, 2016 - pmc.ncbi.nlm.nih.gov
Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide, accounting for
about 9.6 million new cases and 1.5 million deaths annually. The poorest and socially …
about 9.6 million new cases and 1.5 million deaths annually. The poorest and socially …
Drug‐resistant tuberculosis: an update on disease burden, diagnosis and treatment
The emergence of antimicrobial resistance against Mycobacterium tuberculosis, the leading
cause of mortality due to a single microbial pathogen worldwide, represents a growing threat …
cause of mortality due to a single microbial pathogen worldwide, represents a growing threat …
Host-directed therapies for infectious diseases: current status, recent progress, and future prospects
Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …
one in four deaths worldwide and are important causes of long-term functional disability …
The recombinant Bacille Calmette–Guérin vaccine VPM1002: ready for clinical efficacy testing
NE Nieuwenhuizen, PS Kulkarni, U Shaligram… - Frontiers in …, 2017 - frontiersin.org
The only licensed vaccine against tuberculosis (TB), bacille Calmette–Guérin (BCG),
protects against severe extrapulmonary forms of TB but is virtually ineffective against the …
protects against severe extrapulmonary forms of TB but is virtually ineffective against the …
Tuberculosis treatment and management—an update on treatment regimens, trials, new drugs, and adjunct therapies
A Zumla, J Chakaya, R Centis, L D'Ambrosio… - The Lancet …, 2015 - thelancet.com
WHO estimates that 9 million people developed active tuberculosis in 2013 and 1· 5 million
people died from it. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) …
people died from it. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) …
[HTML][HTML] Host blood RNA signatures predict the outcome of tuberculosis treatment
EG Thompson, Y Du, ST Malherbe, S Shankar, J Braun… - Tuberculosis, 2017 - Elsevier
Biomarkers for tuberculosis treatment outcome will assist in guiding individualized treatment
and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of …
and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of …