Compared to several other metal ions with similar chemical properties, zinc is relatively
harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a …

Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

Metal ions, especially with high chemical activity (eg redox-active Cu and Fe) must be
carefully managed in biological systems. The “uncontrolled” activity, eg catalysis of Fenton …

Our understanding of the roles played by zinc in the physiological and pathological
functioning of the brain is rapidly expanding. The increased availability of genetically …

Zinc is a life‐sustaining trace element, serving structural, catalytic, and regulatory roles in
cellular biology. It is required for normal mammalian brain development and physiology …

Programmed cell death or apoptosis is broadly responsible for the normal homeostatic
removal of cells and has been increasingly implicated in mediating pathological cell loss in …

Nitric oxide (NO) and zinc (Zn 2+) are implicated in the pathogenesis of cerebral ischemia
and neurodegenerative diseases. However, their relationship and the molecular mechanism …

Human exposure to heavy metals is inevitable as heavy metals are continually present in
air, water and food. Anthropogenic and industrial activities have rapidly increased the level …

Zn2+ is coreleased with glutamate from mossy fiber terminals and can influence synaptic
function. Here, we demonstrate that synaptically released Zn2+ activates a selective …