T‐cell exhaustion in HIV infection
C Fenwick, V Joo, P Jacquier, A Noto… - Immunological …, 2019 - Wiley Online Library
The T‐cell response is central in the adaptive immune‐mediated elimination of pathogen‐
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …
[HTML][HTML] The diverse function of PD-1/PD-L pathway beyond cancer
The recent success of PD-1 and PD-L1 blockade in cancer therapy illustrates the important
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …
[HTML][HTML] An immune atlas of clear cell renal cell carcinoma
Immune cells in the tumor microenvironment modulate cancer progression and are attractive
therapeutic targets. Macrophages and T cells are key components of the microenvironment …
therapeutic targets. Macrophages and T cells are key components of the microenvironment …
[HTML][HTML] Immune checkpoint blockade in infectious diseases
The upregulation of immune checkpoint molecules, such as programmed cell death protein
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
[HTML][HTML] COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes
I Sánchez-Cerrillo, P Landete, B Aldave… - The Journal of …, 2020 - Am Soc Clin Investig
SARS-CoV-2 is responsible for the development of coronavirus disease 2019 (COVID-19) in
infected individuals, who can either exhibit mild symptoms or progress toward a life …
infected individuals, who can either exhibit mild symptoms or progress toward a life …
The integration of inflammaging in age-related diseases
Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …
physiological systems, depending on a complex interaction between genetic, environmental …
Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders
X Yang, B Su, X Zhang, Y Liu, H Wu… - Journal of leukocyte …, 2020 - academic.oup.com
The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …
Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
L Wu, E Seung, L Xu, E Rao, DM Lord, RR Wei… - Nature Cancer, 2020 - nature.com
Despite the significant therapeutic advances provided by immune-checkpoint blockade and
chimeric antigen receptor T cell treatments, many malignancies remain unresponsive to …
chimeric antigen receptor T cell treatments, many malignancies remain unresponsive to …
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
T cell exhaustion is an induced state of dysfunction that arises in response to chronic
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
Clinical trial of the anti-PD-L1 antibody BMS-936559 in HIV-1 infected participants on suppressive antiretroviral therapy
CL Gay, RJ Bosch, J Ritz, JM Hataye… - The Journal of …, 2017 - academic.oup.com
Background. Reversing immune exhaustion with an anti-PD-L1 antibody may improve
human immunodeficiency virus type 1 (HIV-1)–specific immunity and increase clearance of …
human immunodeficiency virus type 1 (HIV-1)–specific immunity and increase clearance of …