Mitochondria supply cells with energy in the form of ATP, guide apoptosis, and contribute to
calcium buffering and reactive oxygen species production. To support these diverse …

It is generally agreed that engineered cardiovascular tissues require cellular interactions
with the local milieu. Within the microenvironment, the extracellular matrix (ECM) is an …

In patients with pulmonary diseases such as idiopathic pulmonary fibrosis and severe acute
respiratory distress syndrome, progressive pulmonary fibrosis is caused by dysregulated …

Expression of programmed death-ligand 1 (PD-L1) in tumor cells such as lung cancer cells
plays an important role in mechanisms underlying evasion of an immune check point …

Asthma is an obstructive airway disease, with a heterogeneous and multifactorial
pathogenesis. Although generally considered to be a disease principally driven by chronic …

We demonstrate the use of dielectric elastomer actuators (DEAs) for mechanical stimulation
of cells in vitro. The development of living tissues is regulated by their mechanical …

The key role of electro-chemical signals in cellular processes had been known for many
years, but more recently the interplay with mechanics has been put in evidence and …

Heart disease remains the leading cause of morbidity and mortality worldwide. With the
advancement of modern technology, the role (s) of microtubules in the pathogenesis of heart …

Activation of airway smooth muscle (ASM) cells plays a central role in the pathophysiology of
asthma. Because ASM is an important therapeutic target in asthma, it is beneficial to develop …

Oligodendrocytes (OLs) are myelinating cells of the central nervous system. Recent studies
have shown that mechanical factors influence various cell properties. Mechanical stimuli can …