Despite the remarkable advances in cancer diagnosis, treatment, and management over the
past decade, malignant tumors remain a major public health problem. Further progress in …

Intratumor heterogeneity reduces treatment efficacy and complicates our understanding of
tumor progression and there is a pressing need to understand the functions of …

Doxorubicin (DOX) is a cornerstone chemotherapeutic agent for the treatment of several
malignancies such as breast cancer; however, its activity is ameliorated by the development …

A common feature of bacterial, fungal and cancer cell populations upon treatment is the
presence of tolerant and persistent cells able to survive, and sometimes grow, even in the …

Chemotherapy is among the main classical approaches to the treatment of oncologic
diseases. Its efficiency has been comprehensively proven by clinical examinations; …

Neoadjuvant chemotherapy (NAC) is a standard-of-care treatment for locally advanced triple
negative breast cancer (TNBC) before surgery. The early assessment of TNBC response to …

Evolutionary game theory has been highly valuable in studying frequency-dependent
selection and growth between competing cancer phenotypes. We study the connection …

The development of mathematical models of cancer informed by time-resolved
measurements has enabled personalised predictions of tumour growth and treatment …

Resistance to therapy remains a significant challenge in cancer treatment, often due to the
presence of a stem-like cell population that drives tumor recurrence post-treatment …

Tumor heterogeneity contributes significantly to chemoresistance, a leading cause of
treatment failure. To better personalize therapies, it is essential to develop tools capable of …