No common malignancy is as rapidly and inevitably fatal as pancreatic ductal
adenocarcinoma (PDA). This grim fact has driven substantial research efforts into this …

Gemcitabine is an antimetabolite ranking among the most prescribed anticancer drugs
worldwide. This nucleoside analog exerts its antiproliferative action after tumoral conversion …

The purpose of this article is to provide updated recommendations for the treatment of
patients with stage IV non–small-cell lung cancer. A literature search identified relevant …

While chemotherapy provides useful palliation, advanced lung cancer remains incurable
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …

Purpose To explore whether population-related pharmacogenomics contribute to
differences in patient outcomes between clinical trials performed in Japan and the United …

Platinum based therapy is one of the most effectively used chemotherapeutic treatments for
cancer. The mechanism of action of platinum compounds is to damage DNA and drive cells …

The mainstay of acute myeloid leukemia chemotherapy is the nucleoside analog cytarabine
(ara-C). Numerous studies suggest that the intracellular concentrations of the ara-C active …

Cytidine Deaminase Residual Activity in Serum Is a Predictive Marker of Early Severe Toxicities
in Adults After Gemcitabine-Base Page 1 Cytidine Deaminase Residual Activity in Serum Is a …

The inter-individual differences in cancer susceptibility are somehow correlated with the
genetic differences that are caused by the polymorphisms. These genetic variations in drug …

Pharmacokinetics Gemcitabine is a hydrophilic molecule, and three nucleoside transporters
mediate most of its uptake into cells: SLC29A1, SLC28A1, and SLC28A3 (Fig. 1) …