Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

The specialized sets of genes that determine different cell types in yeast are controlled by
combinations of DNA-binding proteins some of which are present only in certain cell types …

The brahma (brm) gene is required for the activation of multiple homeotic genes in
Drosophila. Loss-offunction brm mutations suppress mutations in Polycomb, a repressor of …

The transcriptional adaptor protein Gcn5 has been identified as a nuclear histone
acetyltransferase (HAT). Although recombinant yeast Gcn5 efficiently acetylates free …

Identification of conserved domains or motifs in proteins may aid in the localization and
analysis of important structural and functional regions. We report here a protein sequence …

When yeast cells are grown under conditions of amino acid limitation, transcription of amino
acid biosynthetic genes is increased through the action of the GCN4 transcriptional …

Abstract FAcilitates Chromatin Transcription (FACT) has been considered essential for
transcription through chromatin mostly based on cell-free experiments. However, FACT …

The SAGA complex is a conserved histone acetyltransferase-coactivator that regulates gene
expression in Saccharomyces cerevisiae. SAGA contains a number of subunits known to …

The Saccharomyces cerevisiae transcription factor Spt20/Ada5 was originally identified by
mutations that suppress Ty insertion alleles and by mutations that suppress the toxicity …

Chromatin structure is believed to be important for a number of cellular processes, including
transcription. However, the role of nucleosomes in transcription is not well understood. We …