Because of their potent antitumor activity and their proinflammatory role, natural killer (NK)
cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells …

Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …

Tumor immunotherapy is an artificial stimulation of the immune system to enhance anti-
cancer response. It has become a powerful clinical strategy for treating cancer. The number …

Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in
immunity by killing virally infected or tumor cells and secreting cytokines and chemokines …

Despite major advances in immunotherapy, hepatocellular carcinoma (HCC) remains a
challenging target. Natural Killer (NK) cells are crucial components of the anti-HCC immune …

XPO1 (Exportin-1/CRM1) is a nuclear export protein that is frequently overexpressed in
cancer and functions as a driver of oncogenesis. Currently small molecules that target XPO1 …

Ligation of the inhibitory receptor NKG2A by its ligand HLA-E negatively regulates the
activation of natural killer (NK) cells, as well as subsets of CD8+ T cells and innate T cell …

Innate immunity is the first line of the host immune system to fight against infections. Natural
killer cells are the innate immunity lymphocytes responsible for fighting against virus …

High-risk neuroblastoma (NB) is challenging to treat with 5-year long-term survival in
patients remaining below 50% and low chances of survival after tumor relapse or …

Immunotherapy aims to stimulate the immune system to inhibit tumor growth or prevent
metastases. Tumor cells primarily employ altered expression of human leukocyte antigen …