Dendritic cells (DCs) are a unique class of immune cells that act as a bridge between innate
and adaptive immunity. The discovery of DCs by Cohen and Steinman in 1973 laid the …

The adaptive immune system plays a pivotal role in the host's ability to mount an effective,
antigen‐specific immune response against tumors. CD8+ tumor‐infiltrating lymphocytes …

Glioblastoma (GBM) is the most devastating brain tumor, with associated poor prognosis.
Despite advances in surgery and chemoradiation, the survival of afflicted patients has not …

The spread of COVID-19 is showing huge, unexplained, differences between northern and
southern Italy. We hypothesized that the regional prevalence of specific class I human …

The central nervous system (CNS) possesses powerful local and global immunosuppressive
capabilities that modulate unwanted inflammatory reactions in nervous tissue. These same …

Although high mammographic density is considered one of the strongest risk factors for
invasive breast cancer, the genes involved in modulating this clinical feature are unknown …

The sentinel or tumor-draining lymph node (tdLN) serves as a metastatic niche for many
solid tumors and is altered via tumor-derived factors that support tumor progression and …

Many inorganic nanoparticles are prepared and their behaviors in living systems are
investigated. Yet, common electrolytes such as NaCl are left out of this campaign. The …

Impaired functionality of dendritic cells (DCs) significantly contributes to decreased adaptive
immune responses in aged hosts. The expression of MHC-peptide on the DC surface is the …

Induction of potent tumor-specific cytotoxic T-cell responses is a fundamental objective in
anticancer therapeutic strategies. This event requires that antigen-presenting cells present …