SIRT7: the seventh key to unlocking the mystery of aging

U Raza, X Tang, Z Liu, B Liu - Physiological Reviews, 2024 - journals.physiology.org
Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

SIRT7 in the aging process

FA Lagunas-Rangel - Cellular and Molecular Life Sciences, 2022 - Springer
Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …

Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3

X Zhang, R Cao, J Niu, S Yang, H Ma, S Zhao, H Li - Cell discovery, 2019 - nature.com
Chemical modifications on histones constitute a key mechanism for gene regulation in
chromatin context. Recently, histone lysine β-hydroxybutyrylation (Kbhb) was identified as a …

Advances in cellular characterization of the sirtuin isoform, SIRT7

D Wu, Y Li, KS Zhu, H Wang, WG Zhu - Frontiers in endocrinology, 2018 - frontiersin.org
SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent
histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but …

A click chemistry approach reveals the chromatin-dependent histone H3K36 deacylase nature of SIRT7

WW Wang, M Angulo-Ibanez, J Lyu… - Journal of the …, 2019 - ACS Publications
Using an engineered pyrrolysyl-tRNA synthetase mutant together with tRNACUAPyl, we
have genetically encoded Nε-(7-azidoheptanoyl)-l-lysine (AzHeK) by amber codon in …

SIRT7: a novel molecular target for personalized cancer treatment?

A Ianni, P Kumari, S Tarighi, T Braun, A Vaquero - Oncogene, 2024 - nature.com
The Sirtuin family of NAD+-dependent enzymes assumes a pivotal role in orchestrating
adaptive responses to environmental fluctuations and stress stimuli, operating at both …

The dark side of SIRT7

FA Lagunas-Rangel - Molecular and Cellular Biochemistry, 2024 - Springer
Abstract Sirtuin 7 (SIRT7) is a member of the sirtuin family and has emerged as a key player
in numerous cellular processes. It exhibits various enzymatic activities and is predominantly …

Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones

CF Afonso, MC Marques, JPM António… - Angewandte Chemie …, 2022 - Wiley Online Library
Post‐translational modifications of histones are essential in the regulation of chromatin
structure and function. Among these modifications, lysine acetylation is one of the most …

Sirtuin 2 regulates protein LactoylLys modifications

EQ Jennings, JD Ray, CJ Zerio, MN Trujillo… - …, 2021 - Wiley Online Library
Post‐translational modifications (PTMs) play roles in both physiological and
pathophysiological processes through the regulation of enzyme structure and function. We …

[HTML][HTML] Functions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases

Q Xue, Y Yang, H Li, X Li, L Zou, T Li, H Ma, H Qi… - Genes & …, 2023 - Elsevier
Post-translational modifications (PTM) are covalent modifications of proteins or peptides
caused by proteolytic cleavage or the attachment of moieties to one or more amino acids …