SIRT7: the seventh key to unlocking the mystery of aging
Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …
continuously exposed to a variety of exogenous and endogenous stresses, which engender …
SIRT7 in the aging process
FA Lagunas-Rangel - Cellular and Molecular Life Sciences, 2022 - Springer
Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …
over time. This has been associated with a number of features termed hallmarks of aging …
Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3
Chemical modifications on histones constitute a key mechanism for gene regulation in
chromatin context. Recently, histone lysine β-hydroxybutyrylation (Kbhb) was identified as a …
chromatin context. Recently, histone lysine β-hydroxybutyrylation (Kbhb) was identified as a …
Advances in cellular characterization of the sirtuin isoform, SIRT7
SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent
histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but …
histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but …
A click chemistry approach reveals the chromatin-dependent histone H3K36 deacylase nature of SIRT7
Using an engineered pyrrolysyl-tRNA synthetase mutant together with tRNACUAPyl, we
have genetically encoded Nε-(7-azidoheptanoyl)-l-lysine (AzHeK) by amber codon in …
have genetically encoded Nε-(7-azidoheptanoyl)-l-lysine (AzHeK) by amber codon in …
SIRT7: a novel molecular target for personalized cancer treatment?
The Sirtuin family of NAD+-dependent enzymes assumes a pivotal role in orchestrating
adaptive responses to environmental fluctuations and stress stimuli, operating at both …
adaptive responses to environmental fluctuations and stress stimuli, operating at both …
The dark side of SIRT7
FA Lagunas-Rangel - Molecular and Cellular Biochemistry, 2024 - Springer
Abstract Sirtuin 7 (SIRT7) is a member of the sirtuin family and has emerged as a key player
in numerous cellular processes. It exhibits various enzymatic activities and is predominantly …
in numerous cellular processes. It exhibits various enzymatic activities and is predominantly …
Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones
CF Afonso, MC Marques, JPM António… - Angewandte Chemie …, 2022 - Wiley Online Library
Post‐translational modifications of histones are essential in the regulation of chromatin
structure and function. Among these modifications, lysine acetylation is one of the most …
structure and function. Among these modifications, lysine acetylation is one of the most …
Sirtuin 2 regulates protein LactoylLys modifications
Post‐translational modifications (PTMs) play roles in both physiological and
pathophysiological processes through the regulation of enzyme structure and function. We …
pathophysiological processes through the regulation of enzyme structure and function. We …
[HTML][HTML] Functions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases
Q Xue, Y Yang, H Li, X Li, L Zou, T Li, H Ma, H Qi… - Genes & …, 2023 - Elsevier
Post-translational modifications (PTM) are covalent modifications of proteins or peptides
caused by proteolytic cleavage or the attachment of moieties to one or more amino acids …
caused by proteolytic cleavage or the attachment of moieties to one or more amino acids …