Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information‐containing factors, other …

Introduction: B cell lymphoma 6 (BCL6) is a transcriptional repressor critical for the
development and maintenance of germinal centers (GCs), which are required for generation …

Mutational activation of KRAS is a common oncogenic event in lung cancer, yet effective
therapies are still lacking. Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in …

Intragenic 5‐methylcytosine and CTCF mediate opposing effects on pre‐mRNA splicing:
CTCF promotes inclusion of weak upstream exons through RNA polymerase II pausing …

Terminal differentiation of B cells is an essential process for the humoral immune response
in vertebrates and is achieved by the concerted action of several transcription factors in …

Humoral immunity is critical for limiting Plasmodium parasite infections and the severity of
malaria. Naturally acquired immunity against malaria occurs inefficiently and protection is …

CTCF is overexpressed in several cancers and plays crucial roles in regulating
aggressiveness, but little is known about whether CTCF drives colorectal cancer …

B lymphocytes are generally recognized as the essential component of humoral immunity
and also a regulator of innate immunity. The development of B cells is precisely regulated by …

Multiple genetic aberrations in the regulation of BCL6, including in acetyltransferase genes,
occur in clinically aggressive B-cell lymphomas and lead to higher expression levels and …

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes an aggressive T-cell
malignancy and a variety of inflammatory conditions. The integrated provirus includes a …