[HTML][HTML] miRNA-based biomarkers, therapies, and resistance in Cancer
B He, Z Zhao, Q Cai, Y Zhang, P Zhang… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
Abstract MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in
size, play important roles in gene regulation, and their dysregulation is implicated in human …
size, play important roles in gene regulation, and their dysregulation is implicated in human …
[HTML][HTML] Current trends in drug metabolism and pharmacokinetics
Y Li, Q Meng, M Yang, D Liu, X Hou, L Tang… - … Pharmaceutica Sinica B, 2019 - Elsevier
Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion
(ADME) processes of a drug. Understanding PK properties is essential for drug development …
(ADME) processes of a drug. Understanding PK properties is essential for drug development …
20-HETE in the regulation of vascular and cardiac function
P Rocic, ML Schwartzman - Pharmacology & therapeutics, 2018 - Elsevier
HETE, the ω-hydroxylation product of arachidonic acid catalyzed by enzymes of the
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …
The role of UDP-glycosyltransferases in xenobioticresistance
D Dimunová, P Matoušková, R Podlipná… - Drug metabolism …, 2022 - Taylor & Francis
Uridine diphosphate sugar-utilizing glycosyltransferases (UGTs) are an enzyme superfamily
that catalyzes glycosyl residues transfer from activated nucleotide sugars to acceptor …
that catalyzes glycosyl residues transfer from activated nucleotide sugars to acceptor …
Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
Environmental exposures to hazardous chemicals are associated with a variety of human
diseases and disorders, including cancers. Phase I metabolic activation and detoxification …
diseases and disorders, including cancers. Phase I metabolic activation and detoxification …
[HTML][HTML] Bioengineered miR-328-3p modulates GLUT1-mediated glucose uptake and metabolism to exert synergistic antiproliferative effects with chemotherapeutics
MicroRNAs (miRNAs or miRs) are small noncoding RNAs derived from genome to control
target gene expression. Recently we have developed a novel platform permitting high-yield …
target gene expression. Recently we have developed a novel platform permitting high-yield …
[HTML][HTML] Bioengineered miR-27b-3p and miR-328-3p modulate drug metabolism and disposition via the regulation of target ADME gene expression
Drug-metabolizing enzymes, transporters, and nuclear receptors are essential for the
absorption, distribution, metabolism, and excretion (ADME) of drugs and xenobiotics …
absorption, distribution, metabolism, and excretion (ADME) of drugs and xenobiotics …
MiR-155 and other microRNAs downregulate drug metabolizing cytochromes P450 in inflammation
In conditions of acute and chronic inflammation hepatic detoxification capacity is severely
impaired due to coordinated downregulation of drug metabolizing enzymes and …
impaired due to coordinated downregulation of drug metabolizing enzymes and …
Nuclear receptor phosphorylation in xenobiotic signal transduction
M Negishi, K Kobayashi, T Sakuma… - Journal of Biological …, 2020 - ASBMB
Nuclear pregnane X receptor (PXR, NR1I2) and constitutive active/androstane receptor
(CAR, NR1I3) are nuclear receptors characterized in 1998 by their capability to respond to …
(CAR, NR1I3) are nuclear receptors characterized in 1998 by their capability to respond to …
[HTML][HTML] The 2024 Nobel Prize in Physiology or Medicine: microRNA Takes Center Stage
The Non-coding Journal Editorial Board Members would like to congratulate Victor Ambros
and Gary Ruvkun, who were jointly awarded the 2024 Nobel Prize in Physiology or …
and Gary Ruvkun, who were jointly awarded the 2024 Nobel Prize in Physiology or …