Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming

C Luri‐Rey, G Gomis, J Glez‐Vaz… - Immunological …, 2024 - Wiley Online Library
Antigen cross‐priming of CD8+ T cells is a critical process necessary for the effective
expansion and activation of CD8+ T cells endowed with the ability to recognize and destroy …

The resolution of phagosomes

S Mylvaganam, SA Freeman - Immunological Reviews, 2023 - Wiley Online Library
Phagocytosis is a fundamental immunobiological process responsible for the removal of
harmful particulates. While the number of phagocytic events achieved by a single phagocyte …

A Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy

Y Miao, L Niu, X Lv, Q Zhang, Z Xiao, Z Ji… - Advanced …, 2024 - Wiley Online Library
Pathogen‐mimicking nanoparticles have emerged at the forefront of vaccine delivery
technology, offering potent immune activation and excellent biocompatibility. Among these …

Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy

C Moussion, L Delamarre - Seminars in Immunology, 2024 - Elsevier
Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in
shaping adaptive immunity. DCs have a unique ability to sample their environment, capture …

The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells

GA Gonzales, S Huang, L Wilkinson, JA Nguyen… - Science …, 2024 - science.org
Conventional dendritic cells (cDCs) generate protective cytotoxic T lymphocyte (CTL)
responses against extracellular pathogens and tumors. This is achieved through a process …

[HTML][HTML] Tim4 enables large peritoneal macrophages to cross-present tumor antigens at early stages of tumorigenesis

S Joshi, L López, LG Morosi, R Amadio, M Pachauri… - Cell Reports, 2024 - cell.com
Receptors controlling the cross-presentation of tumor antigens by macrophage subsets in
cancer tissues are poorly explored. Here, we show that TIM4+ large peritoneal …

HOPS-Dependent Endosomal Escape Demands Protein Unfolding

M Zoltek, AL Vázquez Maldonado, X Zhang… - ACS Central …, 2024 - ACS Publications
The inefficient translocation of proteins across biological membranes limits their application
as potential therapeutics and research tools. In many cases, the translocation of a protein …

Emerging potential of immunopeptidomics by mass spectrometry in cancer immunotherapy

Y Minegishi, Y Haga, K Ueda - Cancer Science, 2024 - Wiley Online Library
With significant advances in analytical technologies, research in the field of cancer
immunotherapy, such as adoptive T cell therapy, cancer vaccine, and immune checkpoint …

[HTML][HTML] Making cups and rings: the 'stalled-wave'model for macropinocytosis

RR Kay, JE Lutton, JS King… - Biochemical Society …, 2024 - portlandpress.com
Macropinocytosis is a broadly conserved endocytic process discovered nearly 100 years
ago, yet still poorly understood. It is prominent in cancer cell feeding, immune surveillance …

Design and Evaluation of Synthetic Delivery Formulations for Peptide-Based Cancer Vaccines

K Song, SH Pun - BME frontiers, 2024 - spj.science.org
With the recent advances in neoantigen identification, peptide-based cancer vaccines offer
substantial potential in the field of immunotherapy. However, rapid clearance, low …