Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Senescent cells accumulate throughout the body with advanced age, diseases and chronic
conditions. They negatively impact health and function of multiple systems, including the …

Cellular senescence, an integral component of aging and cancer, arises in response to
diverse triggers, including telomere attrition, macromolecular damage and signaling from …

N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA
modification. m6A modification is a dynamic and reversible post-transcriptional regulatory …

Cellular senescence is a stable form of cell cycle arrest in response to various stressors.
While it serves as an endogenous pro-resolving mechanism, detrimental effects ensue when …

Cellular senescence forms a barrier to tumorigenesis, by inducing cell cycle arrest in
damaged and mutated cells. However, once formed, senescent cells often emit paracrine …

Cellular senescence suppresses cancer by preventing the proliferation of damaged cells,
but senescent cells can also promote cancer though the pro-inflammatory senescence …

Rationale: Wnt signaling regulates key aspects of diabetic vascular disease. Objective: We
generated SM22-Cre; LRP6 (fl/fl); LDLR−/− mice to determine contributions of Wnt …

A small GTPase, Cdc42 is evolutionarily one of the most ancient members of the Rho family,
which is ubiquitously expressed and involved in a wide range of fundamental cellular …

Vascular calcification is prevalent in patients with chronic kidney disease (CKD) and a major
risk factor of cardiovascular disease. Vascular calcification is now recognised as a biological …