Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …

Background: Targeting of drugs to the subcellular compartments represents one of the
modern trends in molecular pharmacology. The approach for targeting mitochondria was …

Skeletal muscle metabolic and contractile properties are reliant on muscle mitochondrial
and myofibrillar protein turnover. The turnover of these specific protein pools is …

Walking exercise is the most effective noninvasive therapy that improves walking ability in
peripheral artery disease (PAD). Biologic mechanisms by which exercise improves walking …

Purpose: It is well established that high-load resistance exercise (HLRE) can stimulate
myofibrillar accretion. Additionally, recent studies suggest that HLRE can also stimulate …

Mitochondria operate as hubs of cellular metabolism that execute important regulatory
functions. Damaged/dysfunctional mitochondria are recognized as major pathogenic …

Although peripheral artery disease (PAD) primarily affects large arteries outside the brain,
PAD is also associated with elevated cerebral vulnerabilities, including greater risks for …

Peripheral arterial disease (PAD) is a prevalent cardiovascular complication of limb vascular
insufficiency, causing ischemic injury, mitochondrial metabolic damage and functional …

The most direct characteristic of muscle atrophy is reduction in muscle mass, which is due to
increased protein degradation or reduced protein synthesis in skeletal muscle. The loss of …

Work from our laboratory documents pathological events, including myofiber oxidative
damage and degeneration, myofibrosis, micro-vessel (diameter= 50–150 μm) remodeling …