Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …

Gene expression is a fundamentally stochastic process, with randomness in transcription
and translation leading to cell-to-cell variations in mRNA and protein levels. This variation …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring …

Genetically identical cells exposed to the same environmental conditions can show
significant variation in molecular content and marked differences in phenotypic …

Engineered systems are often built of recurring circuit modules that carry out key functions.
Transcription networks that regulate the responses of living cells were recently found to obey …

Bacterial gene expression depends not only on specific regulatory mechanisms, but also on
bacterial growth, because important global parameters such as the abundance of RNA …

The genetic and biochemical networks which underlie such things as homeostasis in
metabolism and the developmental programs of living cells, must withstand considerable …

Random fluctuations in genetic networks are inevitable as chemical reactions are
probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such …

Gene expression is an inherently stochastic process: Genes are activated and inactivated by
random association and dissociation events, transcription is typically rare, and many …