The role of hypoxia-inducible factor 1 alpha (HIF-1α) modulation in heavy metal toxicity

M Aschner, AV Skalny, R Lu, A Santamaria… - Archives of …, 2023 - Springer
Abstract Hypoxia-inducible factor 1 (HIF-1) is an oxygen-sensing transcriptional regulator
orchestrating a complex of adaptive cellular responses to hypoxia. Several studies have …

Role of melatonin and quercetin as countermeasures to the mitochondrial dysfunction induced by titanium dioxide nanoparticles

N Nalika, M Waseem, P Kaushik, M Salman… - Life Sciences, 2023 - Elsevier
Aim Due to the growing commercialization of titanium dioxide nanoparticles (TNPs), it is
necessary to use these particles in a manner that is safe, healthy and environmental friendly …

Amelioration of mercuric chloride-induced physiologic and histopathologic alterations in rats using vitamin E and zinc chloride supplement

MG Shalan - Heliyon, 2022 - cell.com
The drastic effects of mercuric chloride and the protective efficiency of vitamin E and zinc
chloride co-supplementation were clearly investigated in this study. Male rats were divided …

Melatonin attenuates manganese-induced mitochondrial fragmentation by suppressing the Mst1/JNK signaling pathway in primary mouse neurons

ZF Liu, K Liu, ZQ Liu, L Cong, MY Lei, J Li, Z Ma… - Science of The Total …, 2022 - Elsevier
Manganese (Mn) toxicity is mainly caused by excessive Mn content in drinking water and
occupational exposure. Moreover, overexposure to Mn can impair mental, cognitive …

Melatonin protects against Titanium Oxide-Induced neurotoxicity: Neurochemical, Neurobehavioral, and histopathological evidences

S Sobhani, AA Tehrani, G Sobhani, S Fatima… - … Trace Element Research, 2023 - Springer
Abstract titania (titanium dioxide, TiO2) is known to induce neurotoxicity and CNS
dysfunctions. Numerous studies have explored the neuroprotective effects of melatonin …

Leek (Allium ampeloprasum var. kurrat) aqueous extract loaded on selenium nanoparticles protects against testis and brain injury induced by mercuric chloride in rats

F Mumtaz, BM Farag, MA Farahat… - Journal of the …, 2024 - Wiley Online Library
BACKGROUND Mercuric chloride (HgCl2) is poisonous to humans and animals and
typically damages the nervous system and other organs. Mercuric chloride exposition …

[PDF][PDF] Resveratrol Administration Ameliorates Hepatotoxicity in Mercuric Chloride-‎ Induced Liver Injury in Rats

HFK Aghetaa, RA Dawood, AK Aladhami - The Iraqi Journal of Veterinary …, 2023 - iasj.net
INTRODUCTION hemical poisoning is one of the recent era health problems due to
exponentially progress of industrial revolution and many heavy metals are introduced to …

Subchronic Low-Dose Methylmercury Exposure Accelerated Cerebral Telomere Shortening in Relevant with Declined Urinary aMT6s Level in Rats

X Wu, P Li, J Tao, X Chen, A Zhang - Toxics, 2023 - mdpi.com
Methylmercury (MeHg) is a global pollutant with established toxic effects on the central
nervous system (CNS). However, early events and early-warning biomarkers of CNS …

Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats

A Yahyazadeh, FM Gur - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Mercury chloride (ME) is a chemical pollutant commonly found in the environment, which
can contribute to undesirable health consequence worldwide. The current study investigated …

Melatonin, Circadian Rhythms, and Sleep: An Opportunity to Understand Mechanisms for Protecting Against Neurodegenerative Disease in Drosophila

HK Dollish, KER Kennedy, MA Grandner… - Sleep and Clocks in …, 2023 - Springer
Research on melatonin's antioxidant and sleep-chronobiotic properties has increased
exponentially over the past 15 years. Resolving the evolutionary progression along which …