[HTML][HTML] hERG K+ channels: structure, function, and clinical significance
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
[HTML][HTML] Serine/threonine phosphatases: mechanism through structure
Y Shi - Cell, 2009 - cell.com
The reversible phosphorylation of proteins is accomplished by opposing activities of kinases
and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the …
and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the …
Voltage-gated ion channels in cancer cell proliferation
Changes of the electrical charges across the surface cell membrane are absolutely
necessary to maintain cellular homeostasis in physiological as well as in pathological …
necessary to maintain cellular homeostasis in physiological as well as in pathological …
Protein Ser/Thr phosphatases–the ugly ducklings of cell signalling
DL Brautigan - The FEBS journal, 2013 - Wiley Online Library
This review traces the historical origins and conceptual developments leading to the current
state of knowledge of the three superfamilies of protein Ser/Thr phosphatases.'PR …
state of knowledge of the three superfamilies of protein Ser/Thr phosphatases.'PR …
[HTML][HTML] Versatile TPR domains accommodate different modes of target protein recognition and function
RK Allan, T Ratajczak - Cell stress and chaperones, 2011 - Elsevier
The tetratricopeptide repeat (TPR) motif is one of many repeat motifs that form structural
domains in proteins that can act as interaction scaffolds in the formation of multi-protein …
domains in proteins that can act as interaction scaffolds in the formation of multi-protein …
Protein phosphatase complement in rice: genome-wide identification and transcriptional analysis under abiotic stress conditions and reproductive development
Background Protein phosphatases are the key components of a number of signaling
pathways where they modulate various cellular responses. In plants, protein phosphatases …
pathways where they modulate various cellular responses. In plants, protein phosphatases …
Small G proteins in the cardiovascular system: physiological and pathological aspects
G Loirand, V Sauzeau, P Pacaud - Physiological reviews, 2013 - journals.physiology.org
Small G proteins exist in eukaryotes from yeast to human and constitute the Ras superfamily
comprising more than 100 members. This superfamily is structurally classified into five …
comprising more than 100 members. This superfamily is structurally classified into five …
Control of cardiac repolarization by phosphoinositide 3-kinase signaling to ion channels
Upregulation of phosphoinositide 3-kinase (PI3K) signaling is a common alteration in
human cancer, and numerous drugs that target this pathway have been developed for …
human cancer, and numerous drugs that target this pathway have been developed for …
Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone
Many nuclear hormones have physiological effects that are too rapid to be explained by
changes in gene expression and are often attributed to unidentified or novel G protein …
changes in gene expression and are often attributed to unidentified or novel G protein …
The role of PP5 and PP2C in cardiac health and disease
J Neumann, P Boknik, U Kirchhefer, U Gergs - Cellular signalling, 2021 - Elsevier
Protein phosphatases are important, for example, as functional antagonists of β-adrenergic
stimulation of the mammalian heart. While β-adrenergic stimulations increase the …
stimulation of the mammalian heart. While β-adrenergic stimulations increase the …