Immunosuppressive mechanisms of regulatory B cells

D Catalán, MA Mansilla, A Ferrier, L Soto… - Frontiers in …, 2021 - frontiersin.org
Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal …

LT Wang, KJ Liu, HK Sytwu, ML Yen… - Stem cells translational …, 2021 - academic.oup.com
Mesenchymal stem cell therapy (MSCT) for immune and inflammatory diseases continues to
be popular based on progressive accumulation of preclinical mechanistic evidence. This …

Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity

K Piekarska, Z Urban-Wójciuk, M Kurkowiak… - Nature …, 2022 - nature.com
Cell-based immunotherapies can provide safe and effective treatments for various disorders
including autoimmunity, cancer, and excessive proinflammatory events in sepsis or viral …

Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance

N Negi, MD Griffin - Stem Cells, 2020 - academic.oup.com
The immunomodulatory potential of mesenchymal stromal cells (MSCs) and regulatory T
cells (T-reg) is well recognized by translational scientists in the field of regenerative …

From AKI to CKD: maladaptive repair and the underlying mechanisms

Z Wang, C Zhang - International journal of molecular sciences, 2022 - mdpi.com
Acute kidney injury (AKI) is defined as a pathological condition in which the glomerular
filtration rate decreases rapidly over a short period of time, resulting in changes in the …

Stem cells: a potential treatment option for kidney diseases

D Liu, F Cheng, S Pan, Z Liu - Stem cell research & therapy, 2020 - Springer
The prevalence of kidney diseases is emerging as a public health problem. Stem cells
(SCs), currently considered as a promising tool for therapeutic application, have aroused …

[HTML][HTML] Safety and preliminary efficacy of mesenchymal stromal cell (ORBCEL-M) therapy in diabetic kidney disease: a randomized clinical trial (NEPHSTROM)

N Perico, G Remuzzi, MD Griffin… - Journal of the …, 2023 - journals.lww.com
Safety and Preliminary Efficacy of Mesenchymal Stromal Cell... : Journal of the American
Society of Nephrology Safety and Preliminary Efficacy of Mesenchymal Stromal Cell (ORBCEL-M) …

The immunomodulatory effects of mesenchymal stem cells on regulatory B cells

J Liu, Q Liu, X Chen - Frontiers in Immunology, 2020 - frontiersin.org
The therapeutic potential of mesenchymal stem cells (MSCs) has been investigated in many
preclinical and clinical studies. This potential is dominantly based on the …

Therapeutic mesenchymal stromal cells for immunotherapy and for gene and drug delivery

G Almeida-Porada, AJ Atala, CD Porada - Molecular Therapy-Methods & …, 2020 - cell.com
Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when
combined, make them ideally suited for cellular-based immunotherapy and as vehicles for …

Mesenchymal stromal cells for transplant tolerance

MA Podestà, G Remuzzi, F Casiraghi - Frontiers in immunology, 2019 - frontiersin.org
In solid organ transplantation lifelong immunosuppression exposes transplant recipients to
life-threatening complications, such as infections and malignancies, and to severe side …