The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is
crucial for transducing signals from a variety of metabolically relevant hormones and …

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and inflammatory …

Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the
pathogenesis of diabetes, contributing to pancreatic β-cell loss and insulin resistance …

Both common forms of diabetes have an inflammatory pathogenesis in which immune and
metabolic factors converge on interleukin-1β as a key mediator of insulin resistance and β …

Signal transducers and activators of transcription (STATs) are latent cytoplasmic
transcription factors that mediate various biological responses, including cell proliferation …

The microRNA-29 (miR-29) family is among the most abundantly expressed microRNA in
the pancreas and liver. Here, we investigated the function of miR-29 in glucose regulation …

Comprehensive phosphoproteomic analysis of small populations of cells remains a
daunting task due primarily to the insufficient MS signal intensity from low concentrations of …

Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes as well as loss of islets
after transplantation. In type 1 diabetes, beta cells are destroyed by immunological …

Cytokines produced by islet-infiltrating immune cells induce β-cell apoptosis in type 1
diabetes. The IFN-γ-regulated transcription factors STAT1/IRF-1 have apparently divergent …

Type 1 diabetes mellitus (T1D) is characterized by severe insulin deficiency resulting from
chronic and progressive destruction of pancreatic beta-cells by the immune system. The …