Metal complexes—a promising approach to target biofilm associated infections
Microbial biofilms are represented by sessile microbial communities with modified gene
expression and phenotype, adhered to a surface and embedded in a matrix of self-produced …
expression and phenotype, adhered to a surface and embedded in a matrix of self-produced …
[HTML][HTML] Recent Development of Fluoroquinolone Derivatives as Anticancer Agents
J Nowakowska, D Radomska, R Czarnomysy… - Molecules, 2024 - ncbi.nlm.nih.gov
Cancer is the second leading cause of death in the world following cardiovascular disease.
Its treatment, including radiation therapy and surgical removal of the tumour, is based on …
Its treatment, including radiation therapy and surgical removal of the tumour, is based on …
Preparation, antioxidant and antibacterial activities of cryptate copper (II)/sulfonate chitosan complexes
H Wu, Y Zhang, H Chen, J Liu, L Xiu… - International Journal of …, 2023 - Elsevier
In this work, we synthesized cryptate copper (II) followed by complexed with sulfonate
chitosan (SCS). After characterization, the evaluation of the antioxidant properties of …
chitosan (SCS). After characterization, the evaluation of the antioxidant properties of …
[HTML][HTML] PK-PD Evaluation of Inhaled Microparticles loaded with Ciprofloxacin-Copper complex in a Rat Model of Chronic Pseudomonas aeruginosa Lung Infection.
F Tewes, B Lamy, J Laroche, I Lamarche… - International Journal of …, 2023 - Elsevier
The potential gain in efficacy of pulmonary administration over IV administration of some
antibiotics such as ciprofloxacin (CIP) may be limited by the short residence time of the drug …
antibiotics such as ciprofloxacin (CIP) may be limited by the short residence time of the drug …
Synthesis, characterization and assessment of anti-quorum sensing activity of copper(II)-ciprofloxacin complex against Pseudomonas aeruginosa PAO1
Quorum sensing (QS) inhibition by metal-antibiotic complexes is a promising strategy for the
management and control of multidrug resistant Pseudomonas aeruginosa infections. We …
management and control of multidrug resistant Pseudomonas aeruginosa infections. We …
Control of the lung residence time of highly permeable molecules after nebulization: Example of the fluoroquinolones
J Brillault, F Tewes - Pharmaceutics, 2020 - mdpi.com
Pulmonary drug delivery is a promising strategy to treat lung infectious disease as it allows
for a high local drug concentration and low systemic side effects. This is particularly true for …
for a high local drug concentration and low systemic side effects. This is particularly true for …
Sorbate metal complexes as newer antibacterial, antibiofilm, and anticancer compounds
AI Abousaty, FM Reda, WA Hassanin, WM Felifel… - BMC microbiology, 2024 - Springer
The ineffectiveness of treatments for infections caused by biofilm-producing pathogens and
human carcinoma presents considerable challenges for global public health organizations …
human carcinoma presents considerable challenges for global public health organizations …
Alternative therapeutics to control antimicrobial resistance: a general perspective
Antimicrobial Resistance (AMR) is a critical global health challenge, and in this review
article, we examine the limitations of traditional therapeutic methods and the emerging role …
article, we examine the limitations of traditional therapeutic methods and the emerging role …
In vitro evaluation of Pseudomonas aeruginosa chronic lung infection models: Are agar and calcium-alginate beads interchangeable?
BGS Torres, R Awad, S Marchand, W Couet… - European Journal of …, 2019 - Elsevier
Animal models of chronic lung infection with P. aeruginosa (PA) are useful tools to improve
antibiotic (ATB) treatment. Two main models based on the pulmonary instillation of PA …
antibiotic (ATB) treatment. Two main models based on the pulmonary instillation of PA …
In vivo efficacy of a dry powder formulation of ciprofloxacin-copper complex in a chronic lung infection model of bioluminescent Pseudomonas aeruginosa
F Tewes, TF Bahamondez-Canas… - European Journal of …, 2020 - Elsevier
A significant limitation of locally delivered treatments for chronic pulmonary infections is
often the short residence time within the airways. Ciprofloxacin (CIP), for example …
often the short residence time within the airways. Ciprofloxacin (CIP), for example …