Nanoparticles (Nps) have revolutionized the landscape of many treatments, by modifying not
only pharmacokinetic properties of the encapsulated agent, but also providing a significant …

Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …

The therapeutic efficacy of drugs is dependent upon the ability of a drug to reach its target,
and drug penetration into tumors is limited by abnormal vasculature and high interstitial …

Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a
commonly used approach for improving the efficiency of drug and gene delivery to target …

ABSTRACT A commonly held view is that nanocarriers conjugated to polyethylene glycol
(PEG) are non-immunogenic. However, many studies have reported that unexpected …

Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

The modification of protein and nanoparticle therapeutics with polyethylene glycol (PEG), a
flexible, uncharged, and highly hydrophilic polymer, is a widely adopted approach to reduce …

Abstract Poly (ethylene glycol)(PEG) as gold standard has been extensively conjugated to
diagnostic and therapeutic agents or decorated on the surface of nanoplatforms, which is …

Upon contact with biofluids, proteins are quickly adsorbed onto the nanoparticle (NP)
surface to form a protein corona, which initiates the opsonization and facilitates the rapid …

RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …