Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the …

In a human menstrual cycle the endometrium undergoes remodeling, shedding and
regeneration, all of which are driven by substantial gene expression changes in the …

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …

Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue
function at the cellular level, yet studies analyzing healthy adult human small intestine and …

Cancer stem cells (CSCs) have been hypothesized to represent the driving force behind
tumour progression and metastasis, making them attractive cancer targets. However …

Little is known about how metabolites couple tissue-specific stem cell function with
physiology. Here we show that, in the mammalian small intestine, the expression of Hmgcs2 …

Modern single-cell technologies allow multiplexed sampling of cellular states within a tissue.
However, computational tools that can infer developmental cell-state transitions reproducibly …

Recent developments in single‐cell transcriptomics have opened new opportunities for
studying dynamic processes in immunology in a high throughput and unbiased manner …

The mammary epithelium comprises two primary cellular lineages, but the degree of
heterogeneity within these compartments and their lineage relationships during …