The integral role of RNA in stress granule formation and function

D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

[HTML][HTML] Stress granules dynamics: benefits in cancer

JI Lee, S Namkoong - BMB reports, 2022 - ncbi.nlm.nih.gov
Stress granules (SGs) are stress-induced subcellular compartments, which carry out a
particular function to cope with stress. These granules protect cells from stress-related …

Tas2R activation relaxes airway smooth muscle by release of Gαt targeting on AChR signaling

YW Zhou, J Sun, Y Wang, CP Chen… - Proceedings of the …, 2022 - National Acad Sciences
Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory
diseases. Bitter receptor–mediated bronchodilation is a potential therapy for asthma, but the …

The roles of G3BP1 in human diseases

Y Ge, J Jin, J Li, M Ye, X Jin - Gene, 2022 - Elsevier
Ras-GTPase-activating protein binding protein 1 (G3BP1) is a multifunctional binding
protein involved in a variety of biological functions, including cell proliferation, metastasis …

Molecular signature to predict quality of life and survival with glioblastoma using Multiview omics model

R Nassani, Y Bokhari, BM Alrfaei - Plos one, 2023 - journals.plos.org
Glioblastoma multiforme (GBM) patients show a variety of signs and symptoms that affect
their quality of life (QOL) and self-dependence. Since most existing studies have examined …

Role of stress granules in tumorigenesis and cancer therapy

T Li, Z Zeng, C Fan, W Xiong - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Stress granules (SGs) are membrane-less organelles that cell forms via liquid-liquid phase
separation (LLPS) under stress conditions such as oxidative stress, ER stress, heat shock …

ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5

JH Jeong, SH Park, H Kim, HY Nam, SH Kim… - … & molecular medicine, 2023 - nature.com
Glioblastoma multiforme (GBM), the most aggressive and malignant glioma, has a poor
prognosis. Although patients with GBM are treated with surgery, chemotherapy, and …

Altering biomolecular condensates as a potential mechanism that mediates cannabidiol effect on glioblastoma

LP Wang, PS Chagas, ÉL Salles, SE Naeini, J Gouron… - Medical Oncology, 2024 - Springer
Glioblastoma (GBM) is an extremely aggressive primary brain tumor with poor prognosis,
short survival time post-diagnosis and high recurrence. Currently, no cure for GBM exists …

Cancer cell adaptability: turning ribonucleoprotein granules into targets

M Lavalée, N Curdy, C Laurent, JJ Fournié… - Trends in cancer, 2021 - cell.com
Stress granules (SGs) and processing bodies (P-bodies) are membraneless cytoplasmic
condensates of ribonucleoproteins (RNPs). They both regulate RNA fate under …

Role of stress granules in modulating senescence and promoting cancer progression: special emphasis on glioma

D Chatterjee, O Chakrabarti - International Journal of Cancer, 2022 - Wiley Online Library
Stress granules (SGs) contain mRNAs and proteins stalled in translation during stress; these
are increasingly being implicated in diseases, including neurological disorders and cancer …